Senior Scientist II, Functional Genomics

Novartis Farmacéutica; Cambridge (MA); On-site; USD 93,000 - 175,000; Full time

Job summary

A leading pharmaceutical company seeks a Senior Scientist II to develop and optimize cell-based assays for high-throughput functional genomic screening in Cambridge, MA. The ideal candidate will possess strong expertise in functional genomics, advanced cell models, and has a PhD with relevant experience. This role offers competitive compensation, including a performance-based cash incentive and comprehensive benefits.

Benefits

401(k) with company contribution

Comprehensive benefits package

Generous time off package

Performance-based cash incentives

Qualifications

• Strong expertise in functional genomics and molecular biology.
• Extensive experience with iPSCs and advanced cell models.
• Familiarity with genomics perturbagens like siRNA and CRISPR.

Responsibilities

• Develop and optimize cell-based assays for genomic screening.
• Stay updated with genomic science advancements.
• Contribute to research publications and present at conferences.

Skills

Cell culture

Genomic screening

Problem-solving

Project management

Education

PhD in biology or relevant field

Job description

Senior Scientist II, Functional Genomics

Job ID REQ-10054504

USA

Summary

We are currently seeking individuals with strong expertise in functional genomics and molecular biology. The ideal candidate will have substantial experience in genomic screening, complex cell models and automation. You will be responsible for developing and optimizing cell-based assays specifically for high-throughput functional genomic screening, with the goal of identifying targets and accelerating therapeutic development.

About the Role

Internal Job Title: Senior Scientist II

Position Location: Cambridge, MA, onsite

We are currently seeking individuals with strong expertise in functional genomics and iPSC-based disease modeling. The ideal candidate will have substantial experience in genomic screening and complex cell models. You will be responsible for developing and optimizing cell-based assays specifically for high-throughput functional genomic screening, with the goal of identifying targets and accelerating therapeutic development.

Your responsibilities include, but are not limited to:

• Develop and optimize cell-based biological assays for high-throughput genomic screening.
• Candidates should have extensive experience in cell culture, particularly with iPSCs and advanced complex cell models such as organoids and primary cells, as well as strong proficiencies in functional genomics.
• Experience with human blood-brain barrier (BBB) models using iPSC-derived cells would be a plus.
• Stay up-to-date with the latest advancements in genomic science and screening methodologies to provide actionable insights for process improvement.
• Contribute to the publication of research findings and present at scientific conferences, keeping the scientific community abreast of cutting-edge developments.
• PhD with 0-2 years in biology (or relevant field), with applicable related experience.
• Proficient with mammalian cell culture and experience with iPS derived cell models/ physiologically relevant in vitro disease models. Expertise with complex models, such as poly-culture or organoids.
• Demonstrated familiarity with both genomics perturbagens, including strengths and liabilities of each class (siRNA, CRISPR, cDNA).
• Strong problem-solving skills and attention to detail, with good troubleshooting and resolving technical challenges in automated assay development.
• Strong organizational and project management skills, with the ability to work in a fast-paced, collaborative environment.

The salary for this position is expected to range between $93,800 and $174,200 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

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The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Division Biomedical Research

Business Unit Pharma Research

Location USA

State Massachusetts

Site Cambridge (USA)

Company / Legal Entity U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.