Senior Scientist II, Early Analytical Peptide Development, Synthetic Molecules

BioSpace; North Chicago (IL); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

401(k) plan

Paid time off

Medical/dental/vision insurance

Long-term incentive programs

Job summary

AbbVie is seeking a Senior Scientist II to conceive, implement, and execute novel analytical research for NCEs, focusing on peptide development and transition from discovery to development. You will collaborate across Analytical R&D, Process Chemistry, QA, and other partners to deliver reliable data and robust methods, in a cross-functional team environment.

The role requires strong analytical chemistry skills, experience with HPLC and MS, and the ability to communicate complex ideas across

Qualifications

• Minimum years of related industry experience per degree: BS 12, MS 10, PhD 4.
• Experience with peptide development and analytical problem solving.
• Experience with HPLC analysis and method development preferred.
• Comfort discussing organic chemistry topics in analytical R&D and with partner functions.

Responsibilities

• Lead peptide product development from an analytical perspective with cross-functional teams.
• Support new peptide development with advanced analytics to drive the pipeline.
• Develop and implement analytical control strategies for drug discovery candidates.
• Independently perform lab research and method development with minimal supervision.
• Interpret and visualize data to support project decisions.

Skills

Peptide development

HPLC analysis

Analytical methods development

Analytical chemistry

Cross-functional collaboration

Education

PhD in Analytical Chemistry

MS/BS in Analytical Chemistry or Pharmaceutical Sciences

Tools

HPLC

Mass Spectrometry

GC

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

For the Senior Scientist IIposition, we are seeking a highly motivated candidate who can conceive, implement and execute novel scientific research and development,independently develop,optimize new methods and techniques to generate reliable and reproducible data in a timelymanner anddemonstrate broad versatile technical expertise.Theywillsupport early phase development of New Chemical Entities (NCEs), particularlysynthetic peptides,in boththepreclinical-and clinical-development spaceand collaborate within the global Analytical R&D organization and with R&D cross-functional partners such as Pre-Clinical Safety (PCS), Process Chemistry, Process Engineering, Drug Product Development (DPD), Quality Assurance (QA),and CMC-RegulatoryAffairs.

This position will focus primarilyon transitioning NCEs from Discovery into Development Sciences and the individual will independentlyserve as an Analytical Research and Development representative in a highly cross-functional team, which includes Discovery, Process Chemistry, Quantitative and Translational ADME Sciences (QTAS), Safety Pharmacology, Pre-Clinical Safety (PCS), and Molecular Profiling and Drug Delivery (MPDD).Candidates should be comfortable discussing organic chemistry topics relevant to analytical chemistry, such as stereoisomers, common functional groups, and pKa values. Experience withpeptide developmentisrequiredandchromatographic analysis (such as HPLC or GC)and Mass Spectrometryishighlypreferred.

Responsibilities

• Responsible forefficientlyleadingand supporting new peptide product development,fromananalytical perspective,while working withcross-functional areasto advance projects through the development pipeline.
• Support newpeptideproduct development with advancedanalytics to drive the pipeline and impactful research initiatives.
• Utilize understanding of a range of analytical techniques to conduct research and development studies related tosynthetic-moleculedrug substances, impurities, and impurity profiling.
• Highly autonomous and productive in performing laboratory researchand/or method development, requiring only minimal direction from or interaction with supervisor.
• Initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• Process, interpret, and visualize data to facilitate project team decisions.
• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates.
• Raises the bar and is never satisfied with the status quo.

Qualifications

• Bachelors, Masters, or Ph.D. inAnalyticalChemistryor Pharmaceutical Sciences(withstrongAnalytical Focus)typically with minimum 12(BS),10(MS), or4(Ph.D.) years related industry experience.
• Strong technical background inpeptide development withexcellent analytical problem-solving skills. Capable of independently developing and troubleshootinganalytical methods.
• Demonstrated experience with HPLC analysis and method development preferred along with expertise and fundamental understanding of spectroscopic techniquesas they relate to peptide development andsmall molecules.
• Comfortable discussing organic chemistry topics within analytical R&D and with partner functions. Hands-on experience with synthetic organic chemistry preferred.
• Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
• Experience in the use of computerized data handling systems.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
• Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.
• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast, grasps the "essence" and can change course quickly where indicated.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html