Senior Scientist II, Computational Biology

Eikon Therapeutics; Millbrae (CA); On-site; USD 191,000 - 231,000; Full time

Benefits offered by this job

401k with company match

Medical/dental/vision coverage (prem/σ

Mental health benefits

Paid time off and holidays

Life/AD&D insurance

Parental leave

Job summary

Eikon Therapeutics in Millbrae, CA is seeking a Senior Scientist II in Computational Biology to lead early drug discovery with quantitative modeling and cross-functional collaboration. You will apply advanced statistics to high-dimensional data, drive experimental strategies, and collaborate with teams designing new experimental systems.

The role emphasizes deep biological reasoning, methodological creativity, and strong communication to advance proprietary discovery platforms and real-world

Qualifications

• PhD or postdoc with strong quantitative training and 7+ years industry experience.
• Proven record in high-impact, peer-reviewed research.
• Experience applying statistics and methods to biology data.

Responsibilities

• Drive development of novel experimental systems and techniques.
• Develop analytical approaches and proof-of-concept tools.
• Analyze multimodal data to extract insights and define interpretation limits.
• Collaborate with computational and experimental teams to ground models in biology

Skills

Bioinformatics

Industry experience

Multi-modal data

Genomics analyses

Python/R

Public datasets

Publications

Education

PhD or Postdoc + 7y industry

Tools

Python/R

Cloud computing

Containerization

Git version control

Job description

Senior Scientist II, Computational Biology

Millbrae, CA

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position

We seek a Senior Scientist in Computational Biology to drive diverse early drug discovery efforts across Eikon’s target portfolio. In this key role, the successful applicant will use their rigorous analytical skills in close collaboration with diverse discovery scientists to conceive and evaluate complex, progress-enabling experiments across our target portfolio. This person will also help shape how Eikon evaluates and adopts novel experimental systems and will partner with colleagues developing quantitative models to ensure that emerging computational methods remain grounded in sound biological reasoning.

About You

For this role, we are seeking an experienced, rigorous, and results-driven computational scientist with a strong track record driving high impact contributions to advance early research drug discovery programs. You are an enthusiastic and generous collaborator who is skilled in both traditional and emergent drug discovery technologies and is comfortable working in a fast-paced, cross-functional environment uniting diverse disciplines and subject matter experts . This role will require someone who is curious, detail-oriented, and a strategic thinker who can draw on deep technical and biological knowledge to synthesize data from diverse internal and external sources to resolve nuanced scientific questions. You bring both scientific depth and methodological creativity to bear on emerging experimental systems and works closely with quantitative modeling colleagues to ground new computational approaches in strong biological reasoning.

What You’ll Do

• Drive the development and adoption of novel experimental systems and techniques relevant to Eikon’s target portfolio, collaborating closely with experimental and computational teams across programs.
• Develop and apply analytical approaches, statistical methods, and proof-of-concept tools to support new experimental strategies.
• Analyze multimodal data to evaluate experimental systems, identify enabling insights, and define the limits of interpretation for biological applications.
• Apply statistical, biological, and experimental expertise to evaluate complex experiments. Distill information from diverse sources to reach relevant and testable biological conclusions.

Qualifications

• Postdoc Fellowship plus 4 years of relevant experience or PhD in bioinformatics, computational biology, or a quantitative field with deep expertise in statistics or method development, plus 7 years of relevant industry experience.
• Hands-on experience developing and applying methods for high-dimensional, multi-modal datasets, including experience designing, evaluating, and integrating high-throughput experiments. Ability to independently define analytical approaches for novel technologies, develop effective solutions, and validate results with minimal oversight.
• Proven experience analyzing complex genomics datasets across one or more technical modalities, such as bulk, single-cell, or spatial transcriptomics, pooled or arrayed CRISPR screens, MAVEs or other multiplexed reporter assays, high content imaging data, Perturb-seq, or other relevant technologies
• Experience working with large consortia and public datasets such as UK Biobank, TCGA, GTEx, ENCODE, gnomAD, and Human Cell Atlas.
• Expertise using one or more high level programming language (e.g., R, Python, or similar) to solve biological problems; well versed in modern coding and computing best practices such as cloud deployment, version control, containerization, etc.
• Demonstrated record of impactful research, evidenced by publications in peer-reviewed journals.
• Excellent interpersonal, written, and verbal communication skills.
• Additional weight will be given to qualified applicants with experience partnering with computational/algorithms teams on statistical or machine learning model development and/or methodological development.

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

• 401k plan with company matching
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

The expected salary range for this role is $191,000 to $231,000 depending on skills, competency, and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

Voluntary Self-Identification

As set forth in Eikon Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

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An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

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