Senior Scientist I/II- Translational Medicine- PKS, ADME (dual level posting*)

Novartis; Cambridge (MA); On-site; USD 90,000 - 183,000; Full time

Benefits offered by this job

Health insurance

Life insurance

Disability benefits

401(k) with company match

Generous PTO

Job summary

Novartis in Cambridge, MA is seeking a Senior Scientist I/II to support discovery and development through ADME assays, build next-generation lab automation, and deliver high-quality data for decision-making.

The role involves planning and executing ADME workflows, advancing automated methods, and contributing to cross-functional teams, with competitive compensation and comprehensive benefits.

Qualifications

• BSc or MSc with relevant experience in drug metabolism and pharmacokinetics.
• BSc: 7+ years; MSc: 4+ years of ADME/DMPK experience. Senior Scientist II level possible.
• Experience in drug discovery or development labs or CRO/Pharma/Biotech preferred.
• Experience with metabolic stability and permeability assays; cell culture a plus.
• Automation integrated with AI-enabled analytics is desirable.

Responsibilities

• Plan, execute and report ADME assays such as metabolic stability and permeability.
• Interpret in vitro ADME data to support discovery and compound optimization.
• Advance automation strategies to expand capacity and standardize execution.
• Deliver fully automated ADME workflows integrated with AI analytics.
• Develop methods for LCMS-MS, HRMS, and ICP-MS bio-analysis.
• Troubleshoot lab instrumentation and automation platforms.
• Manage study timelines, objectives and budgets; track progress.
• Communicate data and strategy to project teams; contribute to reports.
• Participate in cross-department initiatives; complete trainings.

Skills

ADME assays

Automation

LCMS/HRMS/ICP-MS

Education

BSc in relevant field

MSc in relevant field

Tools

Automation platforms

Job description

Summary

LI#-Onsite

Location: Cambridge

Internal Title: Senior Scientist I/II

Support discovery and development projects through the design, development, and execution of in‑vitro ADME assays, while building next generation lab automation capabilities to deliver high‑quality study data for informed decision‑making.

About The Role

Key Responsibilities

• Plan, execute and report ADME assays such as metabolic stability and permeability to support PK Science’s strategies.
• Interpret in vitro ADME data and translate findings to support early discovery, compound optimization and selection.
• Contribute to novel ADME methodologies and expand assay capabilities.
• Advance automation strategies (e.g., liquid handling, assay miniaturization, assay multiplexing) to expand laboratory capacity, standardize execution to reduce manual effort, and strengthen discovery assay operations.
• Execute and/or contribute to fully automated, end‑to‑end ADME assay workflows integrated with AI‑enabled analytics.
• Develop methods to support small and large molecule bio‑analysis using LCMS‑MS, HRMS, and ICP‑MS techniques.
• Troubleshot lab instrumentation and automation platforms.
• Manage study timelines, objectives and budgets, ensure accuracy of project progress in company tracking tools.
• Under management supervision, work to effectively communicate data, strategy and results to the project teams.
• Contribute to internal ADME study reports and regulatory documents (IND, IMPD, NDA, etc.).
• Participate in cross‑departmental teams, department‑wide initiatives and work streams.
• Complete all required organizational trainings and requirements according to corporate timelines.
• Adhere in strict accord to the appropriate SOP, quality and HSE guidelines.

Essential Requirements

• BSc or MSc with relevant experience in drug metabolism and pharmacokinetics or related field.
• BSc: 7+ years; MSc: 4+ years of ADME/DMPK experience. Applicants with additional research/industrial experience may be considered at the Senior Scientist II level
• Experience working in a drug discovery or development laboratory or relevant experience in a CRO, Pharma or Biotech is highly desirable.
• Experience in metabolic stability and permeability assays highly preferrable; cell culture experience is a plus.
• Experience with laboratory automation integrated with AI‑enabled analytics is highly desirable.
• Knowledge of related disciplines (e.g., bioanalytical, toxicology, biomarker) in the drug discovery or development process.
• Ability to work as part of a cross‑functional team in a highly dynamic, matrixed, project‑team environment.
• Strong organizational and project skills with critical thinking and problem‑solving skills.
• Fluent oral and written English
• This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.

The salary for Senior Scientist I position is expected to range between $89,600 and $166,400 per year for Senior Scientist II salary will range between $98,700.00 - 141,000.00 - 183,300.00 USD Annual

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

Why Novartis

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives.

Benefits and Rewards

Learn about all the ways we’ll help you thrive personally and professionally.

Read our handbook (PDF 30 MB)

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e‑mail to [email protected] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.