Senior Scientist I

AbbVie; Waltham (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

AbbVie in Waltham, MA seeks a Senior Scientist I to join Analytical Development. You will drive LC-MS analyses, proteomics, and biophysical assays to characterize biologics across discovery to commercial stages, mentoring junior staff and leading cross-functional collaborations.

The role emphasizes independence, method development, data integrity, and contribution to continuous improvement within the Analytical Characterization Group.

Qualifications

• PhD or Master's in chemistry, biology, biochemistry or related technical discipline with relevant biotech/pharma experience.
• Experience: PhD with 0–3 years in biotech/pharma, or MS with 8+ years.

Responsibilities

• Independently perform LC-MS analyses of AbbVie's biologics to provide sequence verification and modification profiles.
• Independently perform separation methods and biophysical methods to support characterization studies.
• Design and execute experiments for method development and investigations.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic lab notebook; author and review protocols and reports.
• Represent the Analytical Development department in cross-functional teams as characterization lead.
• Maintain laboratory equipment and coordinate services/PMs.
• Demonstrate scientific initiative and creativity in R&D activities.
• Be highly autonomous and productive in lab work with minimal supervision.
• Direct mentorship of junior scientists in the lab.

Skills

Protein Mass Spectrometry

Liquid Chromatography

Capillary Electrophoresis

Protein Biophysical Characterization

Education

PhD in chemistry/biology/biochemistry or related

MS in chemistry/biology/biochemistry or related

Tools

Windows 10

Microsoft Office

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

We are searching for a highly motivated Senior Scientist I to join our Analytical Development team at Waltham, MA. Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages. As a Senior Scientist I, you will be a part of the Analytical Characterization Group (ACG) within the Analytical Development department. ACG focuses on providing routine, investigative, and in-depth characterization as well as proteomics analyses of AbbVie's biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy, and various other biophysical characterization assays. The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within ACG and the Analytical Development department. The incumbent operates with a high degree of independence, contributes project science in their area of expertise, and develops productive collaborations across disciplines.

Responsibilities:

• Independently perform LC-MS analyses (e.g., intact, reduced, sub-unit, peptide mapping, and disulfide bond mapping) of AbbVie's biologics to provide sequence verification, post-translational modification profiles, sequence variant levels, and disulfide bond profiles.


• Independently perform separation methods (e.g., fractionation of variants) and biophysical methods of AbbVie's biologics to support characterization studies.


• Design and execute experiments for method development and/or investigations.


• Generate and communicate precise, reliable, and reproducible data in a timely manner.


• Organize and document experiments and results in an electronic laboratory notebook; author and review protocols, method development reports, and technical characterization reports.


• Represent the Analytical Development department in cross-functional program teams as characterization lead for AbbVie's biologics in development pipeline.


• Maintain laboratory equipment, provide troubleshooting, and coordinate services/PMs.


• Routinely demonstrate scientific initiative and creativity in research or development activities.


• Highly autonomous and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.


• Direct mentorship of junior scientists and others in the lab.

Qualifications

• PhD or Masters in chemistry, biology, biochemistry or related technical discipline with typically 0-3 (PhD) or 8+ (MS) years of relevant experience in a biotech/pharmaceutical industry setting.

Preferred Qualifications

• Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization


• Strong fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.


• Experience with bioinformatics tools to process and analyze mass spectrometry data.


• Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).


• Excellent written communication, oral communication, organization, and multitasking skills.


• Hardworking and motivated to drive both efficiency and quality in a fast-paced and collaborative environment.


• Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling of materials.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.




• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.




• This job is eligible to participate in our long-term incentive programs.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html