Senior Scientist, High-Throughput Sequencing & Screening

Integrated Biosciences, Inc.; Redwood City (CA); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Full health insurance

401(k) plan

Free lunch

Vacation and sick days

Longevity-related benefits

Job summary

Integrated Bio in Redwood City seeks a Scientist or Senior Scientist to own sequencing and high-throughput screening operations, turning compounds and cells into multimodal data: plate-based screens, multiplex RNA-seq, and NovaSeq X runs.

You will collaborate across biology, chemistry, and AI teams to design screens and ensure data quality, model-ready readouts, and scalable workflows. Onsite work at Redwood City with strong equity, health benefits, and visa sponsorship where applicable.

Qualifications

• A Ph.D. in molecular biology, genomics, bioengineering, or a related field.
• Hands-on knowledge of high-throughput screening, including plate-based assay workflows and automation.
• Hands-on knowledge of multiplex RNA-seq using Illumina reagents and the NovaSeq X.
• Strong molecular biology bench skills: library preparation, nucleic acid QC and quantification, and contamination control.
• Care for data quality, including QC metrics, batch effects, and metadata.
• The ability to learn and adapt quickly as part of a small team, and willingness to work hard in service of moving the needle on human aging.
• Methylation sequencing experience (EM-seq, WGBS, or methylation arrays).
• RNA-seq experience with organs, tissues, or whole blood, including extraction from difficult matrices and globin/rRNA depletion.
• Single-cell or spatial transcriptomics experience.
• Scripting for sequencing QC or analysis (Python or R; familiarity with Illumina pipelines such as DRAGEN).
• Interest in the business of biotech, especially therapeutics and drug discovery.

Responsibilities

• Own end-to-end high-throughput screening operations: assay setup, automation, plate handling (96-, 384-, and 1536-well), QC, and data handoff.
• Design and execute multiplex RNA-seq workflows using Illumina reagents, from sample and library preparation through sequencing.
• Plan, load, operate, and QC NovaSeq X runs, and own run integrity from flow cell to data delivery.
• Develop sequencing-based screening readouts with the biology team, including transcriptomic signatures of senescence and aging.
• Partner with the AI and platform team on data formats, metadata standards, and QC gates so every run improves our models.
• Maintain rigorous documentation, reagent inventories, and instrument upkeep.

Skills

High-throughput screening

Library preparation

Nucleic acid QC

Contamination control

Data QC

Batch effects

Metadata

Adaptability

Methylation sequencing

RNA-seq sample prep

Single-cell transcriptomics

Python

R

DRAGEN

Biotech business interest

RNA-seq (Illumina)

NovaSeq X

Education

Ph.D. in molecular biology, genomics, bioengineering, or related field

Tools

RNA-seq (Illumina)

NovaSeq X

Python

R

DRAGEN

Job description

Integrated Bio in Redwood City seeks a Scientist or Senior Scientist to own sequencing and high-throughput screening operations, turning compounds and cells into multimodal data: plate-based screens, multiplex RNA-seq, and NovaSeq X runs.

You will collaborate across biology, chemistry, and AI teams to design screens and ensure data quality, model-ready readouts, and scalable workflows. Onsite work at Redwood City with strong equity, health benefits, and visa sponsorship where applicable.