Senior Scientist, High-Throughput Biology – AI-Driven Discovery

Xaira Therapeutics, Inc.; South San Francisco (CA); Sur place; USD 90 000 - 150 000; Plein temps

Résumé du poste

Xaira Therapeutics, Inc. in the San Francisco Bay Area is seeking a Senior Scientist for a ~9-month contract to lead the design and execution of high-throughput biology experiments in drug discovery.

You will apply functional genomics and synthetic biology approaches, develop HTS assays, and advance new technologies in collaboration with AI-driven protein design teams. The role requires deep lab expertise, strong communication, and a track record in molecular biology, flow cytometry, and data

Qualifications

• Ph.D. in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or a related field.
• 4+ years of postdoctoral or industry experience.
• Proficiency with molecular biology techniques, complex library construction, flow cytometry, and cell line engineering.
• Experience with pooled screening and NGS-based readouts, including library preparation and sequencing QC.
• Experience with high-throughput antibody display technologies, including yeast, phage, or mammalian display, is a plus.
• Familiarity with single-cell genomics workflows (e.g., scRNA-seq, barcoded or multiplexed assays) is a plus.
• Demonstrated ability to troubleshoot complex experimental issues independently and to guide others through them.
• Strong data analysis capabilities, including proficiency with visualization and statistical software (e.g., GraphPad Prism, R, Python).
• Excellent written and verbal communication skills.

Responsabilités

• Lead the design, implementation, and optimization of biochemical, molecular, and cell-based assays to support high-throughput screening platform development.
• Scale high-throughput screening strategies for binder discovery in mammalian systems.
• Evaluate and pilot emerging technologies and experimental workflows to strengthen discovery capabilities, and make recommendations on their adoption.
• Develop and optimize automated workflows, ensuring data quality, reproducibility, and process efficiency.
• Partner with drug discovery, computational biology, and AI-based protein design teams to analyze, interpret, and share insights from screening data.
• Independently manage multiple projects, ensuring timely delivery of high-quality data and alignment with team goals.
• Maintain accurate records of experiments, protocols, and findings, and contribute to internal and external scientific presentations.

Connaissances

Data analysis

GraphPad Prism

R

Python

Troubleshooting

Formation

Ph.D. in Immunology / Molecular Biology / Cell Biology / Biochemistry / Functional Genomics

Outils

Flow cytometry

NGS

Yeast display

Phage display

Mammalian display

Description du poste

Xaira Therapeutics, Inc. in the San Francisco Bay Area is seeking a Senior Scientist for a ~9-month contract to lead the design and execution of high-throughput biology experiments in drug discovery.

You will apply functional genomics and synthetic biology approaches, develop HTS assays, and advance new technologies in collaboration with AI-driven protein design teams. The role requires deep lab expertise, strong communication, and a track record in molecular biology, flow cytometry, and data