Senior Scientist, Gene Delivery and Editing Process Development

Bristol-Myers Squibb; Seattle (WA); On-site; USD 124,000 - 151,000; Full time

Job summary

A leading biopharmaceutical company in Seattle is seeking a Senior Scientist to join their Gene Delivery and Editing Process Development team. The role involves supporting the development of viral vectors that are essential for groundbreaking cell therapies. The ideal candidate will have experience in process development and will support AAV production, collaborating with partners for tech transfer and manufacturing support.

Benefits

Medical, pharmacy, dental and vision care

401(K)

Paid vacation and paid holidays

Qualifications

• 5+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset.
• Subject matter expert in process development.
• Knowledge of late-stage PD activities (e.g. PC, PPQ).

Responsibilities

• Design, execute, and troubleshoot downstream development experiments supporting next-generation AAV production.
• Lead external manufacture of AAV asset(s) at partner CDMO.
• Actively participate and support lab maintenance, buildout, and continuous improvement initiatives.

Skills

End-to-End downstream subject matter expert

Expertise in viral vector process development

Independently motivated with ability to work in cross-functional teams

Ability to communicate clearly and concisely through oral presentation and technical writing

Education

Degree in biological or chemical engineering, biochemistry, or bio-related field

Tools

Process analytical technologies (PAT)

Job description

Working with Us

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Job Description

The Senior Scientist will join the Gene Delivery and Editing Process Development (GDEPD) organization supporting process development, production, and characterization of viral vectors, which are critical to generating BMS’s groundbreaking cell therapies. The candidate will help drive next-generation viral vector platform development and support the advancement of clinical programs.

Responsibilities

• Design, execute, and troubleshoot downstream development experiments supporting next-generation AAV production
• Identify, onboard, and develop novel downstream technologies in collaboration with internal and external partners
• Lead external manufacture of AAV asset(s) at partner CDMO, including FIH tech transfer, regulatory authoring, and life-cycle support through pivotal process development and manufacturing
• Optimize downstream unit operations and support clinical and commercial scale-up

• Provide experimental design and executional support to team members, mentorship of junior staff
• Craft and articulate experimental, project, and program timelines
• Leverage knowledge of business needs to strategically communicate progress, timelines, and impacts to senior leaders in the organization

• Support cross-functional development efforts e.g. upstream process development, high-throughput process development
• Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities
• Support vector attribute science identification initiatives

• Actively participate and support lab maintenance, buildout, and continuous improvement initiatives
• Work independently and within teams to design, execute, and analyze experiments
• Maintain accurate and detailed laboratory notebook and documentation
• Summarize and present data in group meetings and contribute to group discussions and team strategy
• Identify, drive, and champion new initiatives for knowledge management and data warehousing

• Represent GDEPD within cross-functional teams
• Act as vector PD lead on CMC teams
• Support tech transfer and on-going activities with external collaborators and service providers (CDMOs, CROs) including serving as primary point-of-contact
• Author technical reports and study memos
• Publish in peer reviewed journals, present at conferences, interface with broader industry

Basic Qualifications

• Degree in biological or chemical engineering, biochemistry, or bio-related field with 5+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset
• End-to-End downstream subject matter expert
• Subject matter expert in process development
• Expertise in viral vector process development
• Expertise in tech transfer and GMP manufacturing
• Knowledge of late-stage PD activities (e.g. PC, PPQ)
• Working knowledge of scale up parameters for downstream operations
• Proven ability to design experiments with DoE approaches, execute DoE designs and interpret the results
• Independently motivated with ability to work in cross-functional teams
• Able to manage and mentor as many as 3 direct reports
• Experience interfacing with contract manufacturing and development organizations
• Ability to communicate clearly and concisely through oral presentation and technical writing
• Ability to leverage literature, internal and external resources to solve problems
• Desire to identify and advance the cutting edge
• Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment
• Experience giving presentations at industry conferences
• Experience with processes intensification and process analytical technologies (PAT)
• Experience establishing and industry (e.g. vendor) and/or academic collaborations

Preferred Qualifications

• Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing
• Expertise in late-stage biologics PD
• Working knowledge of regulatory affairs as they relate to biologics and ATMPs
• Working knowledge of upstream process development
• Track record of intellectual property generation
• Record of external publication
• Experience with process modeling, mechanistic modeling, and statistical interpretation of results
• Experience with data pipelines and knowledge management
• Experience with single-use technologies
• Experience with late-stage development
• Graduate degree in biotech / bio or chem engineering field (i.e. MS or PhD)

Additional Job Requirements

Position Handles Hazardous Materials

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview

Seattle - WA: $124,190 - $150,483

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: care ers.bms.com/california-residents/

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