Senior Scientist, Formulation and DP Development

Sutro Biopharma; South San Francisco (CA); On-site; USD 155,000 - 168,000; Full time

Job summary

Sutro Biopharma, Inc. is seeking a Senior Scientist, Formulation and DP Development to lead formulation and DP development for biologics and conjugates, and to create robust DP manufacturing processes to advance our pipeline in a fast-paced environment.

You will design and execute stability and in‑use studies, implement fit‑for‑purpose analytical methods for protein characterization, and collaborate with upstream/downstream teams and CMOs to ensure successful tech transfer and regulatory

Qualifications

• BS/MS (12+ years) or PhD (7+ years) in a scientific discipline with demonstrated creativity.
• Strong experience in pre‑formulation screening and protein/antibody/ADC development.
• Experience with in‑use stability studies and compatibility with administration components.
• Ability to design experiments and work independently in a fast‑paced, cross‑functional environment.

Responsibilities

• Lead formulation and DP development for liquids and lyophilized forms for intermediates, drug substances and products.
• Participate in technology transfer to CMOs and cross‑functional projects.
• Design, execute, document stability and in‑use studies to support clinical and manufacturing processes.
• Develop fit‑for‑purpose analytical methods for protein characterization and stability testing.
• Communicate data at meetings and in regulatory filings with clarity and precision.

Skills

Biopharmaceutical formulation

Protein characterization

Analytical method development

cGMP knowledge

Cross-functional collaboration

Education

Pharmaceutical Sciences / Chemistry / Chemical Engineering

Tools

HPLC/UPLC

Capillary electrophoresis

MALS/DLS

DSC/CD/FTIR

Fluorescence spectroscopy

Job description

Senior Scientist, Formulation and DP Development

Sutro Biopharma, Inc. is looking for a technical leader who will report to the Executive Director of Formulation and DP Development. You will be developing new compositions for biologic / conjugated molecules and creating robust DP manufacturing processes to advance Sutro pipeline and enhance our internal and collaborative product development initiatives in a fast‑paced environment.

Responsibilities

• Work within the Formulation and DP Development team to participate in formulation and DP development for phase‑appropriate liquid and lyophilized formulations for intermediates, drug substance and drug products.
• Participate in activities in technology transfer to CMOs.
• Design, execute, document formulation, stability and in‑use/compatibility studies to support the final formulation, clinical administration and manufacturing processes.
• Utilize/implement fit‑for‑purpose analytical methods for biophysical characterization, formulation and process development and stability testing.
• Communicate experimental data verbally at group, department and cross‑functional meetings and through written documents and reports that may be included in regulatory filings.

Qualifications

• BS/MS (12+ years) or PhD (7+ years) of experience in a scientific discipline (Pharmaceutical Sciences, Chemistry, Chemical Engineering, Biomedical Engineering, or related discipline) and demonstrated scientific creativity and contributions.
• Solid technical skills and experience in pre‑formulation screening studies, biophysical/biochemical characterization of proteins, analytical method development and protein/antibody/ADC product development.
• Practical experience with design and execution of in‑use stability studies for biologics and compatibility with administration components.
• Demonstrated ability to design experiments and routinely generate new ideas and original research. High level of scientific initiative and independence. Highly autonomous requiring minimal supervision from manager.
• Analytical instrumentation: chromatographic (HPLC, UPLC, column chromatography), visible and subvisible particle analysis, capillary electrophoresis and/or biophysical techniques (UV‑vis, MALS/DLS, DSC, CD, FTIR, AUC, Fluorescence spectroscopy) for protein characterization are highly desirable.
• Able to cooperate effectively with cross‑functional teams, such as upstream and downstream process development, manufacturing and quality. Ability to quickly adapt to changes in project direction.
• Working knowledge of cGMP and relevant drug product development guidelines and regulations.
• Flexibility to work on multiple projects between departments in a fast‑paced environment is essential.
• Excellent oral and written communication skills and being detail oriented are important attributes.

Salary and Benefits

Anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma’s California based locations will be $155,000 - $168,000 (not including bonus, equity, and benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.

EEO and Diversity Statement

Sutro Biopharma is an equal opportunity employer. We believe in fostering a culture that is inclusive and values diversity in background and opinions. Our company progresses without regard to race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where employees can grow and succeed together.

COVID‑19 Vaccination Policy

We encourage all colleagues to be fully vaccinated for COVID‑19 prior to the first date of employment.

About Sutro Biopharma

Sutro Biopharma, Inc. is advancing a next‑generation antibody‑drug conjugate (ADC) platform designed to deliver single‑ and dual‑payload ADCs that enable meaningful breakthroughs for patients with cancer. By fully optimizing the antibody, linker, and payload, Sutro’s cell‑free platform produces ADCs that are engineered to improve drug exposure, reduce side effects, and expand the range of treatable tumor types. With unique capabilities in dual‑payload ADCs, Sutro aims to overcome treatment resistance and redefine what’s possible in cancer therapy.