Senior Scientist, Downstream Bioprocess & Tech Transfer

Scorpion Therapeutics; Gaithersburg (MD); On-site; USD 114,000 - 182,000; Full time

Benefits offered by this job

Annual bonus

Equity

Job summary

Scorpion Therapeutics is seeking a senior leader in downstream process development to advance monoclonal antibody programs. You will design scale-down models, drive CPP studies, and lead tech transfer for biologics with a focus on process characterization and CMC readiness.

The role requires significant experience in pharma PD/MS&T, strong leadership across disciplines, and willingness to travel domestically and internationally. Join a fast-paced team shaping biotherapeutic development.

Qualifications

• 6+ years in global pharma PD or MS&T for monoclonal antibodies or related biologics.
• Expertise in downstream process development including scale-up and tech transfer.
• Ability to design and execute process characterization studies using scale-down models that inform PPQ strategy.
• Strong understanding of biologics CMC processes including PPQ/BLA readiness; antibody or ADC development preferred.
• Demonstrated technical leadership within cross-functional teams and programs.
• Willing to travel domestically and internationally as required.

Responsibilities

• Develop and qualify scale-down models for downstream purification to support mAb manufacturing.
• Execute studies and FMEA to establish CPPs and PAT ranges for process characterization.
• Lead development and optimization of downstream processes including scale-up and filtration.
• Conduct downstream unit operations: depth filtration, chromatography, viral inactivation/filtration, TFF, formulation.
• Collaborate with cross-functional teams to design experiments and support tech transfers.
• Draft CMC process descriptions, characterization reports and risk assessments; contribute to QA docs.

Skills

Downstream process development

Global pharma PD/MS&T experience

Process characterization studies

Scale-down model design

Cross-functional leadership

Travel willingness

Education

PhD in Biomedical Engineering or Chemical Engineering or Biochemistry (6+ yrs) or MS with 8+ yrs experience

Job description

Scorpion Therapeutics is seeking a senior leader in downstream process development to advance monoclonal antibody programs. You will design scale-down models, drive CPP studies, and lead tech transfer for biologics with a focus on process characterization and CMC readiness.

The role requires significant experience in pharma PD/MS&T, strong leadership across disciplines, and willingness to travel domestically and internationally. Join a fast-paced team shaping biotherapeutic development.