Senior Scientist, Conjugation Biochemistry

Flagship Pioneering; Cambridge (MA); On-site; USD 126,000 - 181,500; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Flagship Pioneering is looking for an experienced Senior Scientist in Cambridge, MA to lead bioconjugation projects. Candidates should have a Ph.D. and over 5 years of relevant industry experience. The role includes designing and synthesizing oligonucleotide-conjugates and collaborating with cross-functional teams.

Benefits include a competitive salary between $126,000 – $181,500, healthcare coverage, and retirement benefits. Join us to be part of an innovative and diverse research team.

Qualifications

• Ph.D. in Biochemistry, Chemistry, or related scientific discipline.
• 5+ years of bioconjugation-related industrial experience.
• Strong problem-solving skills and proactive attitude.

Responsibilities

• Design, synthesize and purify oligonucleotide-conjugates.
• Collaborate with assay development teams.
• Manage and maintain multiple project timelines.

Skills

Bioconjugation

Analytical Characterization

Problem-Solving

Communication

Project Management

Team Collaboration

Education

Ph.D. in Biochemistry, Chemistry, or related discipline

Tools

RP-HPLC

FPLC

SEC

IEX

Job description

Company Description

In today’s healthcare system, disease diagnosis often relies on invasive procedures, such as biopsies, which enable direct interrogation of cellular and tissue health at the suspected source of disease. Due to their invasiveness, cost, and general inconvenience to the patient, biopsies are often conducted after onset of symptomatic disease presenting one of the largest barriers to delivering interventions early in disease progression when they are likely to be most impactful. Flagship Labs 103, Inc. is a privately held early‑stage company that is building advanced technological and computational platforms to pioneer the detection of cellular dynamics from minimally invasive biospecimens that can be leveraged to connect individuals to the most effective interventions to prevent onset and progression of disease.

Job Description

We are seeking an experienced and motivated Senior Scientist to join and lead our conjugation efforts to drive FL103’s programs forward. Ideal candidates will be self‑motivated, independent, and committed to the generation of high‑quality data within a fast‑paced and innovative research team. The Conjugation Biochemist will support ongoing bioconjugation projects in several research and development areas.

Essential Responsibilities

• Design, synthesis, purification and analysis of oligonucleotide‑conjugates on antibodies and other modalities. Develop and optimize conjugation protocols using established and novel chemistries and technologies as part of an assay development platform.
• Collaborate closely with the assay development team to guide and optimize conjugates to support FL103’s programs.
• Work as part of a cross‑functional team to manage and maintain progress against multiple project timelines, deliver routine updates, and communicate progress to the team.
• Establish and maintain excellent working relationships with critical collaborative partners throughout the company to advance discovery research activities to pre‑clinical development.
• Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audiences.
• Maintain updated and well‑organized lab notebooks and batch records.

Required Qualifications

• Ph.D. in Biochemistry, Chemistry, or related scientific discipline.
• 5+ years of bioconjugation‑related industrial experience, preferably in designing, preparing, and validating oligonucleotide conjugates.
• Understanding project timelines and deliverables and plan/coordinate project work accordingly with departmental, functional, and external stakeholders.
• Strong problem‑solving skills and a proactive attitude towards exploring new approaches.
• Demonstrates strong written and verbal communication skills, with the ability to clearly present complex scientific data to cross‑functional and senior leadership teams.
• Hands‑on expertise with current and cutting‑edge bioconjugation techniques for antibodies, proteins, peptides, and other biomolecules.
• Demonstrated hands‑on experience in analytical characterization of conjugates with a strong analytical mindset. Proficiency in purification techniques such as RP‑HPLC, FPLC, SEC, and IEX.
• Able to work independently or in cross‑functional team settings with minimal supervision.
• Adaptable and flexible, able to navigate shifting priorities and handle day‑to‑day challenges with professionalism and confidence in fast‑moving environments.
• Self‑motivated with strong interpersonal, organizational, and communication skills, and able to take a hands‑on approach in a dynamic, fast‑paced, and collaborative environment.

Benefits and Compensation

Salary range for this role is $126,000 – $181,500. Compensation will depend on factors such as qualifications, skills, and experience. FL103 offers healthcare coverage, an annual incentive program, retirement benefits, and a broad range of other benefits.

Equal Employment Opportunity

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status.

Note on Experience

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies

Flagship Pioneering and its affiliated Flagship Lab companies do not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of the company, and the company will not owe any referral or other fees.