Senior Scientist, Computational Oncology

Stellaromics Inc.; San Diego (CA); On-site; USD 140,000 - 190,000; Full time

Benefits offered by this job

Competitive compensation

Collaborative environment

Career development

Job summary

Stellaromics Inc. in San Diego seeks a hands-on Computational Oncology expert to drive spatial biology initiatives, integrating high‑dimensional datasets with biological insight to advance tumor microenvironment understanding.

You will lead computational analyses, collaborate with wet-lab scientists, and develop reproducible workflows for segmentation, deconvolution, and biomarker discovery across platforms like Xenium, CosMx, GeoMx, MERSCOPE and Visium.

Qualifications

• PhD or MS with industry experience in relevant fields.
• Proficient in spatial and single-cell computational concepts.
• Hands-on experience with major spatial platforms or ability to stand up platforms.

Responsibilities

• Lead computational analysis and biological interpretation of high‑dimensional spatial datasets.
• Analyze tumor microenvironment biology, including cellular composition and spatial organization.
• Develop analytical approaches for segmentation, deconvolution, and biomarker discovery.
• Collaborate with wet‑lab scientists on experimental design and validation.
• Maintain reproducible computational workflows for high‑dimensional data.
• Communicate complex findings through presentations and reports.

Skills

Spatial biology

Single-cell analysis

Computational analysis

Biological intuition

Education

PhD in cancer biology or related field

Tools

Xenium

CosMx

GeoMx

MERSCOPE

Visium

Job description

Role Description

• We are seeking a hands‑on Computational Oncology expert to drive our spatial biology initiatives, bringing deep analytical rigor and biological intuition to complex tumor microenvironment datasets. This individual will serve as the core technical anchor for our oncology programs, bridging raw molecular data and high‑resolution biological insight.

Key Responsibilities

• Lead computational analysis and biological interpretation of high‑dimensional spatial and single‑cell oncology datasets.
• Analyze tumor microenvironment biology, including cellular composition, cell states, spatial organization, neighborhood dynamics, immune‑tumor interactions, and tumor heterogeneity.
• Develop and apply analytical approaches for cellular segmentation, deconvolution, spatial neighborhood analysis, biomarker discovery, and tissue architecture characterization.
• Translate complex datasets into biologically meaningful hypotheses and actionable insights for oncology research.
• Partner closely with wet‑lab scientists on experimental design, sample selection, panel design, controls, assay optimization, validation, and quality assessment.
• Apply strong biological judgment to spatial outputs, recognizing whether observed cellular arrangements and tissue architectures reflect biological reality or potential technical artifacts.
• Develop, optimize, and maintain reproducible computational workflows for high‑dimensional spatial datasets.
• Help benchmark and validate new analytical approaches and provide computational insights that inform assay and platform development.
• Collaborate across scientific, computational, engineering, product, and commercial teams to advance Stellaromics’ spatial biology capabilities.
• Engage with external collaborators and commercial partners to understand scientific questions, interpret results, and communicate the value of spatial approaches in oncology.
• Clearly communicate complex scientific findings through presentations, scientific discussions, reports, publications, posters, and/or conference presentations.
• Bring scientific curiosity, ownership, and adaptability to complex problems in a rapidly evolving biotechnology environment.

Qualifications

Essential Qualifications:

• PhD in cancer biology, molecular biology, genomics, computational biology, or a related field (or an MS with equivalent industry experience).
• Working fluency in spatial and single‑cell computational concepts, specifically segmentation, deconvolution, and neighborhood analysis.
• Direct hands‑on experience with major spatial platforms (Xenium, CosMx, GeoMx, MERSCOPE, Visium) or a demonstrated ability to independently stand up complex molecular platforms from scratch.
• Industry experience gained within biotech, pharma, platform vendors, or specialized core facilities.
• Individual contributor role: you prefer hands‑on technical execution over managing direct reports or running a facility.
• Strong spatial intuition and an instinctive eye for data validity.
• Exceptional interpersonal and collaborative communication skills.
• The instinctive eye: can look at a spatial dataset and immediately sense whether cells are where they should be.

Nice‑to‑Have Qualifications:

• Specific domain expertise in CRC or other gastrointestinal oncology tissue types.
• Combined experience working directly with both major spatial platforms and GI/CRC tissues.
• Proven panel design and validation experience tailored for tumor microenvironment applications.
• Comfort communicating complex technical details across bench, computational, and external/commercial audiences.
• Hands‑on wet‑lab proficiency with oncology tissues, including tumor dissociation, IHC/IF, and FFPE processing.

Why Stellaromics?

• Innovative Technology: Be part of a company at the cutting edge of spatial biology and genomics, revolutionizing the way researchers understand biology.
• Impactful Role: You will have a significant impact on the department and the future of the company.
• Collaborative Environment: Work with a talented, passionate team in a culture that values creativity, innovation, and teamwork.
• Career Growth: As a high‑growth company, we offer significant opportunities for professional development and career advancement.

Compensation

An attractive compensation and benefits package based on market pay data will be commensurate with candidate skills, qualifications, and experience.

If you are interested in becoming part of a growing team energized by limitless possibilities, please visit our website at www.stellaromics.com.

Stellaromics is an Equal Opportunity Employer striving to build an inclusive and diverse workplace culture.