Senior Scientist, Computational Biology

Eikon Therapeutics; Millbrae (CA); On-site; USD 178,000 - 215,000; Full time

Benefits offered by this job

401k plan with company matching

Medical (premiums covered 95%) and 100

Mental health and wellness benefits

Weeklong summer and winter shutdowns

Generous PTO and holidays

Life/AD&D Insurance 100% covered

Enhanced parental leave

Daily subsidized lunch on-site

Job summary

Eikon Therapeutics seeks a Senior Scientist in Computational Biology to lead analytical efforts across its target portfolio and collaborate with discovery scientists. The role emphasizes rigorous data analysis, integration of multimodal data, and close partnership with quantitative modeling to ensure biologically grounded approaches.

You will contribute to experimental design, method development, and interpretation of complex datasets, while working in a fast-paced, cross-functional environment

Qualifications

• PhD or MD with strong computational biology background or Postdoc + 2 years with 5 years industry experience.
• Experience designing analytical approaches for novel technologies and validating results with minimal oversight.
• Proven genomics experience across bulk, single-cell, spatial transcriptomics, CRISPR screens, or related assays.
• Proficiency in one or more programming languages (R/Python) and modern coding practices.

Responsibilities

• Drive development and adoption of novel experimental systems in coordination with experimental and computational teams.
• Develop analytical approaches and tools to support new experimental strategies.
• Analyze multimodal data to derive enabling biological insights and define interpretation limits.
• Collaborate with modeling colleagues to ground new computational methods in biology.

Skills

High-dimensional data analysis

Programming in R/Python

Cross-functional collaboration

Statistical methodology

Communication

Education

PhD in bioinformatics/ computational biology

Tools

R

Python

Cloud computing

Job description

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position

We seek a Senior Scientist in Computational Biology to drive diverse early drug discovery efforts across Eikon’s target portfolio. In this key role, the successful applicant will use their rigorous analytical skills in close collaboration with diverse discovery scientists to conceive and evaluate complex, progress-enabling experiments across our target portfolio. This person will also help shape how Eikon evaluates and adopts novel experimental systems and will partner with colleagues developing quantitative models to ensure that emerging computational methods remain grounded in sound biological reasoning.

About You

For this role, we are seeiking an experienced, rigorous, and results-driven computational scientist with a strong track record driving high impact contributions to advance early research drug discovery programs. You are an enthusiastic and generous collaborator who is skilled in both traditional and emergent drug discovery technologies and is comfortable working in a fast-paced, cross-functional environment uniting diverse disciplines and subject matter experts . This role will require someone who is curious, detail-oriented, and a strategic thinker who can draw on deep technical and biological knowledge to synthesize data from diverse internal and external sources to resolve nuanced scientific questions. You bring both scientific depth and methodological creativity to bear on emerging experimental systems and works closely with quantitative modeling colleagues to ground new computational approaches in strong biological reasoning.

What You’ll Do

• Drive the development and adoption of novel experimental systems and techniques relevant to Eikon’s target portfolio, collaborating closely with experimental and computational teams across programs
• Develop and apply analytical approaches, statistical methods, and proof-of-concept tools to support new experimental strategies
• Analyze multimodal data to evaluate experimental systems, identify enabling insights, and define the limits of interpretation for biological applications
• Apply statistical, biological, and experimental expertise to evaluate complex experiments. Distill information from diverse sources to reach relevant and testable biological conclusions

Qualifications

• Postdoc Fellowship plus 2 years of relevant experience or PhD in bioinformatics, computational biology, or a quantitative field with deep expertise in statistics or method development, plus 5 years of relevant industry experience.
• Hands-on experience developing and applying methods for high-dimensional, multi-modal datasets, including experience designing, evaluating, and integrating high-throughput experiments. Ability to independently define analytical approaches for novel technologies, develop effective solutions, and validate results with minimal oversight.
• Proven experience analyzing complex genomics datasets across one or more technical modalities, such as bulk, single-cell, or spatial transcriptomics, pooled or arrayed CRISPR screens, MAVEs or other multiplexed reporter assays, high content imaging data, Perturb-seq, or other relevant technologies
• Experience working with large consortia and public datasets such as UK Biobank, TCGA, GTEx, ENCODE, gnomAD, and Human Cell Atlas.
• Expertise using one or more high level programming language (e.g., R, Python, or similar) to solve biological problems; well versed in modern coding and computing best practices such as cloud deployment, version control, containerization, etc.
• Demonstrated record of impactful research, evidenced by publications in peer-reviewed journals.
• Excellent interpersonal, written, and verbal communication skills.
• Additional weight will be given to qualified applicants with experience partnering with computational/algorithms teams on statistical or machine learning model development and/or methodological development.

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

• 401k plan with company matching
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

The expected salary range for this role is $178,000 to $215,250 depending on skills, competency, and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

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