Senior Scientist, Cell Therapy Upstream Scale-Up

BioSpace; Waltham (MA); On-site; USD 130,000 - 170,000; Full time

Benefits offered by this job

Health benefits

14 weeks parental leave

Career growth opportunities

AI and digital platforms

Job summary

Sanofi Inc. in Waltham, MA is seeking a Principal Scientist to join the Genomic Medicine Cell Therapy Process Development Group.

The role centers on leading scale-up bioprocesses from bench to pilot scales (200L-2000L) and driving robust, scalable cell culture methods. You will collaborate with process development scientists, translate bench findings into manufacturing-ready processes, and present findings to senior management.

Qualifications

• Masters in Chemical Engineering or related field with 6+ years in large-scale bioreactors.
• PhD with 4+ years in industry related to large-scale bioreactors.
• Strong background in cell culture bioreactor operations and scale-up technologies.
• Experience in biotech/pharmaceutical industry within a cell culture role and operational excellence.
• Experience with perfusion processes at various scales.
• Understanding of engineering principles related to cell culture processes.
• Ability to lead matrix teams for operations and lab management.

Responsibilities

• Lead scale-up activities from bench scale to pilot scale (200L-2000L) applying engineering principles to ensure process comparability at large scale.
• Collaborate with process development scientists to translate laboratory findings into scalable manufacturing processes.
• Review and approve JSAs written by equipment owners and provide feedback.
• Train employees to adopt best practices for safety, efficiency and operational success.
• Build robust internal interfaces with the CMC community and promote best practices.
• Demonstrate expertise in upstream process operations at all scales.
• Lead root cause analysis investigations for process deviations and equipment failures at pilot scale.
• Present findings and results to senior management, external stakeholders, and industry leaders at national/international conferences.

Skills

Cell culture bioreactor operations

Scale-up technologies

Process automation

Cross-functional leadership

Bioprocess engineering

Education

Masters in Chemical Engineering

PhD in related field

Tools

Bioreactor control systems

Job description

Sanofi Inc. in Waltham, MA is seeking a Principal Scientist to join the Genomic Medicine Cell Therapy Process Development Group.

The role centers on leading scale-up bioprocesses from bench to pilot scales (200L-2000L) and driving robust, scalable cell culture methods. You will collaborate with process development scientists, translate bench findings into manufacturing-ready processes, and present findings to senior management.