Senior Scientist - Cardiometabolic Disorders

BioSpace; Thousand Oaks (CA); On-site; USD 150,000 - 210,000; Full time

Job summary

Amgen is seeking a Senior Scientist in Cardiometabolic Disorders to drive biology research, identify therapeutic targets, and guide drug discovery programs. The role combines bench science with leadership, focusing on osteoporosis and metabolic disease, with opportunities to mentor and advance program milestones.

The candidate will perform mechanistic studies, validate targets with human genetics where possible, and collaborate across functions to deliver robust preclinical data and portfolio

Qualifications

• PhD, PharmD or MD with strong biomedical training and post‑doc experience in bone metabolism and metabolic disease.
• Proven ability to design mechanistic studies and generate reproducible high‑quality data.

Responsibilities

• Conceptualizing and proposing drug targets for bone and cardiometabolic disease.
• Designing and performing in vitro and in vivo experiments; data interpretation.
• Communicating results through written and oral presentations; cross‑functional collaboration.
• Leading and mentoring a team of scientists; contributing to publication efforts.
• Documenting studies in ELN and study reports.
• Advancing therapeutic candidates in Cardiometabolic Portfolio.

Skills

Target ideation

In vivo pharmacology

In vitro pharmacology

Data analysis

Scientific communication

Cross-functional collaboration

Manuscripts and posters

Genetics data mining

Data reproducibility

Education

PhD

PharmD

MD

Masters with bone metabolism experience

Bachelors with bone disease experience

Tools

Immunoblotting

Immunocytochemistry

RT-qPCR

Immunoprecipitation

ELISA

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year.

Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist - Cardiometabolic Disorders

What You Will Do

Lets do this. Lets change the world. In this vital role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients.

The proposal and advancement of drug discovery programs will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies.

Critical thinking, ingenuity, the ability to independently design mechanistic studies and conduct reproducible in vivo and in vitro pharmacology studies with high technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical for this role.

You will initially work at the bench and/or vivarium conducting in vivo and/or in vitro preclinical studies with a focus on osteoporosis and metabolic disease. Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research.

As part of the team, you will also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio.

Key Responsibilities

• Conceptualizing and proposing therapeutic targets for the treatment of bone disease and cardiometabolic disease
• Designing and performing in vitro and/or in vivo experiments
• Independently performing data analysis and interpreting results
• Communicating scientific results through written and oral presentations
• Collaborating with teams from other functions in the company to advance therapeutic candidates
• Documenting studies in electronic laboratory notebooks and study reports.
• Advising colleagues in areas of expertise

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a professional with these qualifications.

Basic Qualifications

• Doctorate degree PhD
• OR
• PharmD
• OR
• MD [and relevant post-doc where applicable]
• OR
• Masters degree and 3 years of experience in bone metabolism and bone disease
• OR
• Bachelors degree and 5 years of experience in bone metabolism and bone disease

Preferred Qualifications

• PhD with postdoctoral experience in bone metabolism and metabolic disease (industry experience is strongly preferred)
• Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patients
• Exceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality data
• Technical mastery of general molecular biology and cell-signaling analysis techniques including immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, and ELISA
• Basic knowledge of statistical methods applied in a consistent and rigorous manner to all data sets generated
• Excellent written and oral communication skills and interpersonal skills that enable effective team interactions and communication of key data to all key stakeholders
• A strong ability to collaborate cross-functionally in a multidisciplinary environment is critical
• Capability to deliver high quality manuscripts, posters and presentations for internal and external peer-reviewed publication and conference attendance.
• Understanding of human genetics and genomic data mining for target identification are a plus.
• A high level of commitment to ensuring data reproducibility and data integrity

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.