Senior Scientist, Cardiometabolic Diseases and Obesity - Target Validation

Valo Health; Lexington (MA); On-site; USD 80,000 - 140,000; Full time

Job summary

An innovative technology company is seeking a Senior Scientist to lead the wet-lab validation of drug targets for obesity and diabetes. In this pivotal role, you will leverage your expertise in metabolism and drug discovery to translate human data insights into effective therapies. Collaborating with a multidisciplinary team, you will develop and execute experimental plans, conduct high-quality laboratory experiments, and contribute to impactful scientific advancements. This is an exciting opportunity to be part of a mission-driven organization that is transforming the drug discovery process and improving patient outcomes.

Qualifications

• PhD with 5+ years in related fields or equivalent experience.
• Expertise in human in vitro systems and drug discovery.

Responsibilities

• Design and execute target validation strategies using human cell assays.
• Generate experimental plans for validating therapeutic targets.

Skills

Metabolism expertise

Drug discovery experience

Human in vitro systems

Cell culture

Molecular biology

Imaging

Genetic manipulation

Functional assays development

Communication skills

Collaboration with multidisciplinary teams

Education

PhD in Biological Sciences

MS in Biological Sciences

BS in Biological Sciences

Job description

Senior Scientist, Cardiometabolic Diseases and Obesity - Target Validation

Lexington, Massachusetts, United States

About Us

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. Disease doesn’t wait, so neither can we.

We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together.

About the Role...

Valo is looking for a Senior Scientist to play a pivotal role in wet-lab validation of drug targets for obesity, type 2 diabetes, and cardiovascular diseases that have been identified using Valo’s human-centric Opal computational platform. This position requires expertise in metabolism, some experience in drug discovery, and a passion for translating human data insights to develop new therapies for complex diseases. In this role, you will be responsible for designing and executing target validation strategies using human cell assays to build confidence in the translation of candidate drug targets to diseases of interest.

What You’ll Do…

• Generate experimental plans that will enable validation of novel therapeutic targets.
• Develop and build human cellular functional assays in metabolic cell types to enable interrogation of novel drug targets.
• Perform experiments and generate data in laboratory in collaboration with Valo’s tissue and cell model experts and/or leveraging CROs to support target validation projects as well as ongoing preclinical drug discovery projects.
• Generate data with high quality standards and document in electronic lab notebook.
• Provide thought leadership and guidance within your project teams on obesity, T2D, and/or cardiovascular disease biology, staying abreast of emerging trends and advancements in the field.

What You Bring…

• A PhD in Biological Sciences or related field with 5+ years of experience (or MS with 9+ years of experience or BS with 11+ years of experience) and deep expertise in one or more of the following areas: obesity, diabetes, liver biology, skeletal muscle biology, adipose tissue biology, inflammation.
• Expertise in human in vitro systems including cell culture, molecular biology, imaging, genetic manipulation, and development of functional assays.
• Experience in discovery stage preclinical drug discovery programs and with target validation projects.
• Track record of impactful scientific contributions as demonstrated by high impact publications.
• Strong oral and written communication, presentation and interpersonal skills.
• Experience collaborating with multidisciplinary teams.

You May Also Bring…

• Experience working in in vivo/ex vivo systems.
• Experience working with and managing projects at external vendors/CROs.

More on Valo

Valo Health, LLC (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. Founded by Flagship Pioneering and headquartered in Lexington, MA. Valo also has offices in New York, NY. To learn more, visit www.valohealth.com.

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