Senior Scientist, Cardiometabolic Diseases and Inflammation - Translational Biology

Valo Health; Lexington (MA); On-site; USD 111,000 - 170,000; Full time

Job summary

A leading biotechnology firm is seeking a Senior Scientist for Cardiometabolic Diseases and Inflammation. This role focuses on executing translational biology plans for drug discovery, requiring expertise in cardiometabolic disease biology. The ideal candidate will collaborate with diverse teams, leveraging in vitro and in vivo models to validate drug targets and biomarkers. Join a mission-driven team dedicated to transforming drug discovery through innovative AI technology.

Qualifications

• Deep expertise in cardiometabolic diseases and inflammation.
• Hands-on experience in preclinical drug development programs.
• Experience in designing experiments for novel targets.

Responsibilities

• Execute translational biology strategies to correlate in vitro/in vivo data.
• Design and execute experiments for biomarker identification.
• Collaborate with project team leads and scientists to generate high-quality data.

Skills

Tissue Inflammation

Cardiovascular Immunology

Obesity (Adipose Tissue Biology)

Liver Biology

Preclinical Drug Development

Collaboration with Multidisciplinary Teams

Education

PhD in Biological Sciences

MS with 9+ years of experience

BS with 11+ years of experience

Job description

Senior Scientist, Cardiometabolic Diseases and Inflammation - Translational Biology

Join to apply for the Senior Scientist, Cardiometabolic Diseases and Inflammation - Translational Biology role at Valo Health

Senior Scientist, Cardiometabolic Diseases and Inflammation - Translational Biology

Join to apply for the Senior Scientist, Cardiometabolic Diseases and Inflammation - Translational Biology role at Valo Health

Get AI-powered advice on this job and more exclusive features.

About Us

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we.

About Us

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we.

We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us?

About The Role...

Valois looking for a senior Scientist to play a pivotal role in the lab executing translational biology plans for various drug discovery programs in obesity, type 2 diabetes, and cardiovascular disease for targets that have been identified using Valo’s human-centric Opal computational platform. This position requires expertise in both the biology of cardiometabolic disease and inflammation, a passion for hands on translation of human data driven insights into new therapies, and hands on experience in preclinical drug development programs. In this role, you will be responsible for designing and executing translational biology plans in collaboration with project team leads to demonstrate in vitro/in vivo correlation including pk/pd assessments, omics profiling of cells and tissues, and discovery/demonstration of cellular and in-vivo biomarkers. This role will be critical to deliver high quality data to build confidence in the translation of disease models and will be responsible for delivering biomarker data packages on various teams and presenting to both internal and external stakeholders. You will collaborate with team leaders, subject matter experts, computational scientists, and tissue engineers. You will participate on project teams as a translational biology subject matter expert and help shape Valo’s preclinical drug development process.

What You’ll Do…

• Perform hands on experiments in the lab and generate data in the laboratory in collaboration with Valo’s other biology experts and/or leveraging CROs to support ongoing drug discovery projects
• Execute translational biology strategies to demonstrate in vivo/in vitro correlation in cells and/or animal models
• Work with internal teams and external CROs to design and execute in vivo pk/pd, efficacy, and biomarker experiments
• Design and execute experiments to identify biomarkers for novel targets and build biomarker strategies suitable for programs of various stages.
• Build functional biomarker assays to enable interrogation of novel drug targets
• Generate data with high quality standards and document them in electronic lab notebook
• Provide thought leadership and guidance in your expert area of biology, staying abreast of emerging trends and advancements in the field related to tissue and peripheral biomarkers of varying types (safety, predictive, patient segmentation, disease response…)
  
  

What You Bring…

• A PhD in Biological Sciences or related field with 5+ years of experience (or MS with 9+ years of experience or BS with 11+ years of experience) and deep expertise in two or more of the following areas: Tissue Inflammation, Cardiovascular immunology, obesity (adipose tissue biology) or liver biology.
• Expertise with in vitro human cell systems and ability to work across varying systems (PBMCs, primary tissue cells, organoids)
• Experience with in vivo models of human CVM/Obesity (mouse, rat, pig)
• Experience working with external vendors/CROs
• Experience with drug discovery programs and biomarkers linked to Mechanism of Action
• Strong oral and written communication, presentation and interpersonal skills
• Experience in collaborating with multidisciplinary teams in preclinical drug development
  
  

You May Also Bring…

• Experience with immunology techniques such as flow cytometry, ELISA, and Luminex
• Experience generating samples for multi-omics profiling, RNAseq, Metabolomics, and Lipidomics
  
  

More on Valo

Valo Health, LLC (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative diseases. Founded by Flagship Pioneering and headquartered in Lexington, MA. Valo also has offices in New York, NY. To learn more, visit www.valohealth.com.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

Referrals increase your chances of interviewing at Valo Health by 2x

Get notified about new Senior Scientist jobs in Lexington, MA.

Boston, MA $111,000.00-$170,000.00 3 hours ago

Scientist - Process Research & Development

Analytical Method Development Scientist & Team Lead – GMP Environment

Principal Scientist , Analytical Science Lead

Cambridge, MA $156,000.00-$296,500.00 2 weeks ago

Senior Scientist, Drug Substance Development and Manufacturing

Greater Boston $115,000.00-$140,000.00 2 days ago

Scientist/Senior Scientist, Chemical Development and Manufacturing

Senior Scientist, Computational Chemistry

Scientist 3/Senior Scientist, Clinical Pharmacology

Senior Principal Research Scientist, Analytical Chemistry

Cambridge, MA $156,000.00-$296,500.00 3 weeks ago

Research Associate/Scientist – Physical Vapor Deposition

Principal Scientist, Drug Product Development

Cambridge, MA $149,858.00-$185,119.00 3 days ago

Senior Scientist, Pharmaceutical Development CMC (CONTRACT)

Senior Principal Scientist, Translational Development, Pancreatic Cancer Disease Lead

Principal Scientist - Small Molecule Process Development

Senior Scientist I - Advanced Development Team

We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.