Senior Scientist, BioDesign, BioTherapeutics Discovery

Biogen; Cambridge (MA); On-site; USD 122,000 - 163,000; Full time

Job summary

An established industry player is seeking a Senior Scientist to lead innovative projects in antibody discovery and engineering. This role offers the opportunity to collaborate with external partners, utilizing cutting-edge machine learning techniques to optimize therapeutic candidates. You will guide the development of antibody-oligonucleotide and protein fusion therapeutics, ensuring high-quality outputs while fostering cross-functional teamwork. Join a dynamic environment where your strategic vision and expertise will drive advancements in biologics, making a significant impact on healthcare. Embrace the chance to work with a talented team dedicated to delivering life-changing medicines.

Benefits

Medical, Dental, and Vision Insurance

Fitness & Wellness Programs

Paid Vacation and Holidays

401(k) with Company Match

Tuition Reimbursement

Employee Stock Purchase Plan

Paid Maternity and Parental Leave

Short- and Long-Term Disability Insurance

Qualifications

• Deep expertise in antibody structure and engineering.
• Experience managing antibody discovery through CROs.

Responsibilities

• Manage external antibody discovery through CROs.
• Design and develop antibody-oligonucleotide therapeutics.

Skills

Antibody Engineering

Machine Learning

Project Management

Antibody Developability Assessment

Communication Skills

Education

Ph.D. in Biochemistry

Master’s Degree in Related Field

Tools

10x Genomics

Biologics Data Management Platforms

Job description

Job Description

About This Role

The Senior Scientist role in the Biotherapeutics Discovery and Delivery group within BioDesign will collaborate closely with CROs and external partners to deliver high-quality therapeutic candidates efficiently. Leveraging expertise in antibody engineering principles, structure, and characterization, you will strategically guide antibody discovery and optimization. This role also involves designing and developing antibody-oligonucleotide and protein fusion therapeutics, utilizing machine learning techniques for hit triage, lead optimization, and identification of sequence liabilities. Extensive cross-functional collaboration is essential for advancing novel antibody therapeutics into the pipeline. Your strategic vision, innovation focus, and effective execution will significantly impact Biogen’s biologics capabilities.

What You’ll Do

• Manage external antibody discovery through CROs and collaborative partnerships
• Strategically apply antibody engineering and optimization approaches
• Conduct antibody developability assessments
• Collaborate with internal and external partners with machine learning expertise to apply ML strategies for hit triage, lead optimization, and identifying sequence liabilities
• Design and develop antibody-oligonucleotide and protein fusion therapeutics
• Oversee project timelines and deliverables to ensure high-quality therapeutic antibody candidates
• Lead cross-functional teams to integrate antibody discoveries into pipeline programs
• Identify and implement strategic innovations within antibody discovery and engineering
• Interpret and oversee analysis of single-cell technology data (e.g., 10x Genomics)
• Maintain clear, effective communication with internal stakeholders and external collaborators
• Ensure thorough antibody characterization and rigorous quality control

Who You Are

You are a strategic thinker with deep expertise in antibody structure, engineering, and characterization, passionate about collaborating externally and driving therapeutic innovations. You excel in cross-functional leadership and have a proven track record of advancing complex biologics from discovery to the pipeline.

Qualifications

Required Skills

• Ph.D. in biochemistry, chemical biology, or a related field with 2-5 years experience, or a Master’s degree with 6-8 years relevant industry experience.

• Proven experience managing antibody discovery through external partnerships (CROs)

• Deep expertise in antibody developability assessment and engineering
• Proficiency with machine learning methods for antibody optimization, hit triage, and sequence liability evaluation
• Experience in designing antibody-oligonucleotide or protein fusion therapeutics
• Strong project management skills for delivering high-quality candidates on schedule
• Excellent communication skills for effective collaboration internally and externally
• Broad knowledge of antibody applications in therapeutic pipeline development

Preferred Skills

• Experience with single-cell technologies (10x Genomics) and/or display platforms (yeast).
• Familiarity with biologics data management and integration platforms

• Experience developing complex biologics such as bispecific antibodies, fusion proteins, or engineered scaffolds.

Additional Information

The base salary range for this position is $122,000 - $163,000.Base salary offered isdetermined though an analytical approach utilizing a combination of factorsincluding, but not limited to, relevant skills & experience, job location, and internal equity.Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees and theirfamilies'physical, financial, emotional,andsocial well-being;including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off(Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 days off for Personal Significance
• 80 hours of sick timeper calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.