Senior Scientist, Analytical Development (Small Molecules)

Alumis; South San Francisco (CA); On-site; USD 112,000 - 135,000; Full time

Benefits offered by this job

Stock options

Annual bonus

Health insurance

Genentech shuttle

Cell phone stipend

Unlimited PTO

Free onsite gym

Job summary

Alumis Inc. is a precision medicines company seeking a Sr. Scientist I of Analytical Development to build and lead analytical efforts from preclinical through late-stage clinical development.

You will support method development, validation, transfer, and regulatory documentation with CMOs/CTLs in a fast-paced environment. Located in South San Francisco, CA, this role emphasizes analytical capability across UPLC/HPLC, LC-MS, KF, and dissolution testing, with strong emphasis on regulatory

Qualifications

• BS/MS in chemistry or pharmaceutical sciences with 5+ years of experience in analytical development
• Experience with analytical techniques for small drug molecules and oral solid formulations required, including UPLC/HPLC, LC-MS, KF, dissolution testing, IR, particle size analysis, and solid-state characterization techniques
• Proven track record in applying analytical techniques to solve challenging problems
• Experience in working with CMOs and CTLs
• Experience in early to late-stage drug development
• Strong organizational and communication skills
• Comfortable in a fast-paced small company environment and a strong team player
• Experience and knowledge in ICH, cGMP and regulatory requirements

Responsibilities

• Support development, validation, and transfer of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTLs
• Execute and/or support the in-house method development activities using UPLC/HPLC, LC-MS, KF, and dissolution instrumentation and techniques for Phase 1 to late-stage drug development
• Review CMO/CTL analytical data (in-process, release, and stability data), protocols and reports
• Trend stability and release data using statistical methods
• Assist in investigation for various non-conformance events at CMOs/CTLs
• Collaborate with CMC team, QA and CMOs/CTLs towards timely generation and approval of documents
• Communicate scientific results (oral and written) in a clear and concise manner within cross-functional teams
• Author technical reports and documents in support of regulatory filing
• Assist in preparation of CMC documents for regulatory submissions (IND, IMPD, and/or NDA)

Skills

Analytical development

CMOs/CTLs experience

Drug development (early to late-stage)

Communication

Teamwork

Regulatory compliance

Education

BS/MS in chemistry or pharmaceutical sciences

Tools

UPLC/HPLC

LC-MS

KF

Dissolution testing

IR

Particle size analysis

Solid-state characterization

Job description

Alumis Inc. is a precision medicines company seeking a Sr. Scientist I of Analytical Development to build and lead analytical efforts from preclinical through late-stage clinical development.

You will support method development, validation, transfer, and regulatory documentation with CMOs/CTLs in a fast-paced environment. Located in South San Francisco, CA, this role emphasizes analytical capability across UPLC/HPLC, LC-MS, KF, and dissolution testing, with strong emphasis on regulatory