Senior Safety Scientist: Pharmacovigilance & Risk Lead

Revolution Medicines, Inc.; San Francisco (CA); On-site; USD 164,000 - 205,000; Full time

Job summary

Revolution Medicines, Inc. is seeking a Senior Safety Scientist I to provide safety science and pharmacovigilance support across the RevMed portfolio.

You will oversee safety for clinical studies, review protocols, IBs, ICFs, and DSURs, and participate in cross-functional teams to manage risk and ensure regulatory compliance. You will develop a strong safety profile understanding, perform signal detection, and contribute to regulatory filings while collaborating with study teams and external

Qualifications

• A relevant postgraduate qualification (e.g., MD, PharmD, PhD/MSc in a Life sciences discipline).
• 3+ years of drug development experience with at least 1 year in drug safety.
• Proven success in creating and sustaining strong relationships with internal and external partners.
• Broad understanding of safety science, PV (GVP, GCP), and risk management.
• Ability to lead and influence in a fast-paced environment.
• Strong presentation skills and ability to summarize key considerations.
• Excellent written and verbal communication.
• Therapeutic area experience in oncology.

Responsibilities

• Proactive medical safety surveillance of ongoing clinical trials and management of safety signals.
• Prepare and present safety data summaries to stakeholders.
• Medical review of ICSRs, routine safety data review, and literature reviews.
• Contribute knowledge of relevant drug class and safety issues.
• Identify potential clinical safety issues and recommend risk mitigation.
• Contribute to sections of protocols, IBs, ICFs, DSURs, and labeling.
• Ensure safety components of study reports, publications, and regulatory documents.
• Lead signal detection and evaluation for lifecycle risk/benefit assessment.
• Support regulatory filings and safety queries from agencies.
• Collaborate with study teams, CROs, investigators, and vendors.

Skills

Safety Science

Pharmacovigilance

GVP/GCP knowledge

Relationship building

Clinical trial safety

Leadership

Communication

Oncology

Education

Postgraduate Life Sciences

Job description

Revolution Medicines, Inc. is seeking a Senior Safety Scientist I to provide safety science and pharmacovigilance support across the RevMed portfolio.

You will oversee safety for clinical studies, review protocols, IBs, ICFs, and DSURs, and participate in cross-functional teams to manage risk and ensure regulatory compliance. You will develop a strong safety profile understanding, perform signal detection, and contribute to regulatory filings while collaborating with study teams and external