Senior Safety Physician - CNS

Ladders; United States; Remote; USD 222,000 - 356,000; Full time

Benefits offered by this job

401(k) retirement plan

Pension

Comprehensive medical, dental, vision

Prescription drug benefits

Flexible spending accounts

Life insurance

Job summary

Unknown company in Pharmaceuticals & Biotech is seeking a Senior Safety Physician - CNS to provide medical safety leadership for late-stage clinical programs. Remote US-based role (no visa sponsorship).

You will evaluate emerging data, guide risk mitigation, and support global submissions while partnering with regulatory and cross-functional teams. The role requires an MD/DO or equivalent, 5+ years in drug safety/pharmacovigilance, and strong knowledge of FDA/EMEA/ICH regulations.

Qualifications

• MD, DO, or equivalent medical degree required.
• 5+ years of experience in Drug Safety/Pharmacovigilance or a related field.
• Experience with late-stage clinical development and NDA submissions.
• Proven ability to drive safety evidence generation and risk mitigation strategies.
• Expertise in safety signal evaluation and benefit-risk assessment.
• Strong knowledge of global pharmacovigilance regulations, including FDA, EMEA/EU, and ICH.
• Excellent clinical judgment and cross-functional collaboration skills.

Responsibilities

• Provide medical safety oversight for late-stage clinical studies.
• Review and interpret individual and aggregate safety data.
• Lead safety surveillance and signal management activities.
• Contribute to regulatory documents such as DSURs and NDA submissions.
• Support regulatory interactions with health authorities globally.
• Collaborate with cross-functional teams on safety input and strategies.
• Communicate safety findings effectively to senior leadership.

Skills

Pharmacovigilance

Late-stage development

Safety signal evaluation

Risk mitigation

Cross-functional collaboration

Medical judgment

Education

MD/DO or equivalent medical degree

Job description

For our client, we are seeking a Senior Safety Physician - CNS to join the team of a leader in the Pharmaceuticals & Biotech space. This role will provide medical safety leadership for late-stage clinical development programs, with a focus on ensuring robust safety oversight and informed benefit-risk decisions. The position partners closely with clinical, regulatory, and cross-functional stakeholders to evaluate emerging data, guide risk mitigation, and support global submissions. It is a high-impact opportunity for a physician who brings deep pharmacovigilance expertise and strong scientific judgment to complex development activities. Location: Remote - US based candidates only, no visa sponsorship available. Compensation: $222,000 – $356,400 annually.

Responsibilities

• Provide medical safety oversight for late-stage clinical studies
• Review and interpret individual and aggregate safety data
• Lead safety surveillance and signal management activities
• Contribute to regulatory documents such as DSURs and NDA submissions
• Support regulatory interactions with health authorities globally
• Collaborate with cross-functional teams on safety input and strategies
• Communicate safety findings effectively to senior leadership

Qualifications

• MD, DO, or equivalent medical degree required
• 5+ years of experience in Drug Safety/Pharmacovigilance or a related field
• Experience with late-stage clinical development and NDA submissions
• Proven ability to drive safety evidence generation and risk mitigation strategies
• Expertise in safety signal evaluation and benefit-risk assessment
• Strong knowledge of global pharmacovigilance regulations, including FDA, EMEA/EU, and ICH
• Excellent clinical judgment and cross-functional collaboration skills

Benefits

• Eligibility for a company-sponsored 401(k) and pension
• Comprehensive medical, dental, vision, and prescription drug benefits
• Flexible spending accounts for healthcare and dependent care
• Life insurance and death benefits
• Vacation benefits and leave of absence options
• Well-being benefits, including employee assistance programs and fitness benefits

Our client is an equal opportunity employer. We encourage you to apply even if you don’t meet every qualification—your background could be exactly what this team needs.