Senior Research Technician RNA Synthesis

Mass General Brigham; Cambridge (MA); Hybrid; USD 60,000 - 95,000; Full time

Job summary

An established industry player is seeking a motivated Senior Research Technician to join their innovative RNA Therapeutics Core team. This role involves developing novel RNA-based medicines and technologies, emphasizing collaboration and attention to detail. Candidates will engage in various lab operations, including inventory management and safety protocol implementation, while utilizing their expertise in molecular biology techniques. Join a forward-thinking organization that values groundbreaking medical discoveries and offers a hybrid work environment, allowing you to contribute to impactful research while enjoying flexibility in your work life.

Qualifications

• Bachelor's degree in life sciences with 3+ years lab experience.
• Proficiency in molecular biology techniques and RNA synthesis.

Responsibilities

• Perform routine lab procedures including RNA synthesis and purification.
• Maintain inventory and manage lab safety protocols.

Skills

Molecular Biology Techniques

RNA Synthesis

Cloning

PCR

Electrophoresis

Data Recording

Interpersonal Skills

Education

Bachelor's Degree in Life Sciences

Tools

HPLC

Silica Purification

Flow Filtration

Job description

Site: Mass General Brigham Incorporated

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

GENERAL SUMMARY / OVERVIEW:

The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system. The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients. The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies.

We are seeking a motivated and technically proficient Senior Research Technician to join our RNA Therapeutics Core (RTC) team. The candidate will participate in developing novel RNA-based medicines and technologies, including RNA synthesis, purification, and analytical methods, producing high-quality RNA preparations for experimental applications and external parties. Responsibilities include lab operations such as inventory management, equipment maintenance, and safety protocol implementation. Candidates should have experience in research labs, proficiency in molecular biology techniques like cloning, PCR, electrophoresis, and preferably hands-on RNA synthesis experience. They should be detail-oriented, organized, and eager to work collaboratively.

Qualifications

Qualifications:

• Bachelor's degree in life sciences, biochemistry, or chemistry with at least 3 years of lab experience
• Good organizational skills and attention to detail
• Ability to reproduce work accurately
• Computer literacy
• Methodical data recording skills
• Strong interpersonal and communication skills
• Professionalism and dedication to excellence

Preferred Competencies:

• Experience with mRNA, circular RNA, or long non-coding RNA
• Experience with in vitro transcription and purification
• RNA process development experience
• Lab management skills

Principal Duties and Responsibilities

• Perform routine procedures such as in vitro transcription, silica purification, flow filtration, HPLC, cloning, gel electrophoresis, plasmid purification
• Record quality metrics with accuracy and reproducibility
• Develop new RNA synthesis and purification processes, including automation
• Operate lab equipment and learn new instruments
• Follow safety protocols and use PPE
• Develop and enforce safety procedures in compliance with regulations
• Train lab staff in biosafety and emergency procedures, liaise with safety offices
• Maintain inventory of reagents and supplies, manage ordering and documentation
• Participate in meetings and suggest operational improvements
• Communicate effectively within the team
• Perform other duties as assigned

Additional Job Details

Remote Type: Hybrid

Work Location: 65 Landsdowne Street

Scheduled Weekly Hours: 40

Employee Type: Regular

Work Shift: Day (United States of America)

EEO Statement

Mass General Brigham is an Equal Opportunity Employer. All qualified applicants will receive consideration without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, or other protected status. Reasonable accommodations are provided for individuals with disabilities. Applicants requiring accommodation should contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

Our competency framework defines effective leadership behaviors critical for success, evaluated through observable skills and behaviors across ten competencies, used for performance evaluation, hiring, and development.