Senior Research Scientist - DMPK

Indiana Ag Connection; Indianapolis, Northern (IN, KY); Hybrid; USD 120,000 - 160,000; Full time

Benefits offered by this job

relocation packages

2 weeklong shutdowns (US)

8-week parental leave

Employee Resource Groups

Annual bonus offering

Flexible work arrangements

6% 401K matching

Job summary

Elanco is seeking a Senior Research Scientist - DMPK to lead early DMPK strategies in discovery and pre-clinical programs. You will design and interpret in vitro and in vivo DMPK studies to guide molecule progression and optimization.

Join a global team at the Indianapolis HQ in a hybrid work setting, with opportunities to collaborate with external partners and present data to leadership as part of go/no-go decisions.

Qualifications

• Advanced degree in Pharmacology, Chemistry, Veterinary/Medical Sciences, or related field.
• 4+ years in discovery/pre-clinical DMPK in pharma or academia.
• Experience with PK/PD data interpretation and early-phase DMPK characterization.

Responsibilities

• Serve as PK/DMPK scientific lead across discovery and pre-clinical teams.
• Design, execute, and monitor in vitro DMPK/ADME and in vivo PK/PD studies.
• Collaborate with cross-functional teams and external CROs; communicate findings clearly.

Skills

DMPK/PK

ADME profiling

In vitro / In vivo

Cross-functional collaboration

Scientific communication

Education

PhD in Pharmacology/Drug Metabolism

MS/PhD with equivalent experience

Tools

Phoenix WinNonlin

Monolix

Job description

### Job Details#### Job Title:Senior Research Scientist - DMPK#### Location:,, ,#### Company:#### Industry Sector:#### Industry Type:#### Career Type:#### Job Type:Full Time#### Minimum Years Experience Required:N/A#### Salary:### Get Job Alerts**Career Type:****Country:** USAI agree to receive alerts from and to the .Your alert was created successfully.x## General Alert Saved* The listings below are jobs matching the criteria you've selected for your General Alert on.Criteria selected was:* General alert saved for .* General alert notifications will be sent weekly on Monday.* Please note that you can only have one general alert active at any given time. Creating a new general alert will override an existing general alert.* Visit the to manage your alerts# Senior Research Scientist - DMPK| Number of Years Experience: | Minimum Education Completed: | || Education Major / Discipline Category: | Most Recent / Current Occupation: | |**At Elanco (NYSE: ELAN) - it all starts with animals!****As a global leader in animal health, we are dedicated to innovation and delivering products and services to prevent and treat disease in farm animals and pets.** **At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose - all to Go Beyond for Animals, Customers, Society and Our People.****At Elanco, we pride ourselves on fostering a diverse and inclusive work environment. We believe that diversity is the driving force behind innovation, creativity, and overall business success. Here, you'll be part of a company that values and champions new ways of thinking, work with dynamic individuals, and acquire new skills and experiences that will propel your career to new heights.****Making animals' lives better makes life better - join our team today!**As a Senior Research Scientist - DMPK, you will serve as a subject matter expert in drug metabolism and pharmacokinetics for discovery and pre-clinical research projects. In this role, you will be responsible for designing and implementing DMPK and PK/PD strategies that guide compound optimization, de-risking and accelerating early R&D programs through candidate selection and progression into the development pipeline.**Your Responsibilities:**- Serve as the PK/DMPK scientific lead across multidisciplinary discovery and pre-clinical research teams, establishing strategies to guide small and large molecule candidates toward nomination.- Design, execute, and monitor in vitro DMPK/ADME and in vivo PK/PD profiling studies to evaluate target exposure, bioavailability, metabolism, and drug interaction risks.- Integrate DMPK findings with pharmacology and toxicology data to build robust lead profiles, perform IVIVC or mechanistic modeling, and drive go/no-go progression decisions.- Collaborate cross-functionally across global R&D and partner with external CROs and academic collaborators to access specialized technologies and advance early pipeline packages.- Prepare and deliver clear scientific summaries, reports, and presentations on DMPK findings to enable evidence-based governance decisions.**What You Need to Succeed (minimum qualifications):**- Education: Advanced scientific degree (PhD, PharmD, DVM, or Master's/Bachelor's degree with equivalent level of experience) in Pharmacology, Chemistry, Veterinary/Medical Sciences, or related scientific discipline.- Required Experience: A minimum of 4 years of experience in pharmaceutical industry or academia in discovery and pre-clinical DMPK research, with demonstrated experience in both small and large molecule drug development.- Strong foundational expertise in early-phase DMPK/ADME characterization, PK/PD data interpretation, and proficiency in PK software tools (such as Phoenix WinNonlin, Monolix, or equivalent).**What will give you a competitive edge (preferred qualifications):**- Experience with mechanistic PK modeling and/or physiologically-based pharmacokinetic (PBPK) modeling.- Strong chemistry background with understanding of compound structures, classes, and in vitro profiling.- Familiarity with veterinary drug development and species-specific considerations in animal metabolism and pharmacokinetics.- Demonstrated experience managing and collaborating with external contract research organizations (CROs) and academic partners.- Proven track record of cross-functional collaboration and delivering clear scientific presentations to diverse technical and non-technical audiences.**Additional Information:**- Travel: Up to 10% of domestic and international travel- Location: Global Elanco Headquarters - Indianapolis, IN - Hybrid Work Environment**Elanco Benefits and Perks:**We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include:* Multiple relocation packages* Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)* 8-week parental leave* 9 Employee Resource Groups* Annual bonus offering* Flexible work arrangements* Up to 6% 401K matchingElanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected statusElanco may use automated tools, including AI, to support parts of our recruitment process, such as reviewing applications against job-related criteria and/or transferrable skills. These tools help ensure a consistent, structured evaluation, but they do not make hiring decisions. All decisions involve a human reviewer. For more information on how we handle personal data, please see our Elanco Workforce Privacy Notice.#LI-MW1Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected statusElanco may use automated tools, including AI, to support parts of our recruitment process, such as reviewing applications against job-related criteria and/or transferrable skills. These tools help ensure a consistent, structured evaluation, but they do not make hiring decisions. All decisions involve a human reviewer. For more information on how we handle personal data, please see our Elanco Workforce Privacy Notice.To apply please click on APPLY TO THIS POSITIONJob Post Date: 10/01/26Here are some other jobs you may be interested in applying for.| | || - | - || Elanco Indianapolis, Indiana | Elanco Indianapolis, Indiana || Elanco Indianapolis, Indiana | |2 people are interested in this job.