Senior Research Associate V

R&D Partners; San Carlos (CA); On-site; USD 111,000 - 121,000; Full time

Benefits offered by this job

Medical insurance

401k plan

Employee Assistance Program

Long-term disability

Weekly payroll

Online timecard approval

Job summary

R&D Partners in San Carlos, CA is seeking a Senior Research Associate V for 12-month contract work in the Protein Development and Clinical Manufacturing group. The role focuses on executing plate-based analytical methods to measure protein concentration and quality for cell-free protein synthesis materials, with primary ELISA and Bradford assay responsibilities.

You will support method qualification, reagent management, and apply methods to process characterization studies, while maintaining

Qualifications

• BS in Chemistry, Analytical Chemistry, Biochemistry, or related field with at least 5 years of pharmaceutical/biotech industry experience, OR MS in a related field with at least 3 years of pharmaceutical/biotech industry experience.
• 10+ years of total laboratory experience.

Responsibilities

• Independently performs complex laboratory studies, analyzes data, troubleshoots methods and supports development activities.
• Perform sandwich ELISA and Bradford total protein assays on raw material lysates and in-process samples to support process characterization and process development studies.
• Perform additional protein analysis such as GFP activity assays, Capillary Western (Jess and Leo), and A280/SoloVPE.
• Execute method fit-for-purpose studies and support drafting and revision of test methods.
• Qualify and bridge critical reagents and maintain reagent inventory.
• Maintain good documentation practices in electronic lab notebook (Benchling) and reports.
• Assist in troubleshooting instrumentation, assay variability, and test results.
• Participate in group meetings, present results, and report outcomes clearly.
• Work with lab automation to create high-throughput methods (robotics) including automated ELISA on the Tecan EVO.

Skills

Analytical chemistry

ELISA

Data analysis

Troubleshooting

Record keeping

Team player

Lab automation

Education

Bachelor's degree in Chemistry/Analytical Chemistry/Biology

Master's degree in related field

Tools

HPLC

Capillary Western (Jess/Leo)

Bradford assay

Benchling

Tecan EVO

Biomek

Job description

We are hiring a Senior Research Associate V to support our biotechnology client's product development projects within the Protein Development and Clinical Manufacturing group. You will play a key role in executing and maintaining the plate-based analytical methods that measure protein concentration and quality for cell-free protein synthesis raw materials and in-process intermediates. The successful candidate will be the primary operator for the lysate ELISA and Bradford assays, support method qualification and critical reagent management, and apply these methods to process characterization studies. This position is for a scientific role which will be lab based, and will require excellent scientific judgment, independence, precise and consistent data generation and thorough record keeping.

This is a 12-month contract based in San Carlos, California.

Responsibilities

• Independently performs complex laboratory studies, analyzes data, troubleshoots methods and supports development activities.
• Perform sandwich ELISA (RNA synthetase and RNA polymerase lysates) and Bradford total protein assays on raw material lysates and in-process samples to support process characterization and process development studies.
• Perform additional protein analysis as needed, including GFP activity assays, Capillary Western (Jess and Leo), and A280/SoloVPE.
• Execute method fit-for-purpose studies (accuracy, repeatability, intermediate precision) and support drafting and revision of test methods.
• Qualify and bridge critical reagents (antibodies, reference standards, assay controls) and maintain reagent inventory.
• Maintain good documentation practices for recording experimental plans and results in the electronic lab notebook (Benchling) and associated reports.
• Assist in troubleshooting of instrumentation, assay variability, and test results.
• Participate in group meetings, present results of work, interpret data, and report results in an accurate manner.
• Work with lab automation to create high throughput methods leveraging liquid handling and robotic technologies, including automated ELISA on the Tecan EVO.
• Work in collaboration with other scientists/SMEs to design experiments, train backup analysts, and advance more powerful analytical techniques.

Qualifications

• BS in Chemistry, Analytical Chemistry, Biochemistry, or a related field with at least 5 years of pharmaceutical/biotech industry experience, OR MS in a related field with at least 3 years of pharmaceutical/biotech industry experience. Candidates should also possess 10+ years of total laboratory experience.
• Strong technical understanding in analytical chemistry and biochemistry. Hands-on proficiency with plate-based immunoassays (ELISA) and colorimetric protein assays (e.g., Bradford, BCA); experience with HPLC, CE-SDS, or Western blotting is a plus.
• Experience with method qualification or validation activities, and accurate data analysis and interpretation of experimental results related to process characterization.
• Ability to think critically and demonstrate troubleshooting and problem-solving skills.
• Maintain accurate records of experimental procedures, results and conclusion in compliance with regulatory guidelines.
• Team player, proactive and willing to work in a collaborative team environment.
• Scientific creativity and curiosity for applying new technologies to complex analytical challenges; experience with liquid-handler programming (Tecan, Biomek) preferred.

Pay

• $80.32-$87.61

Why Choose R&D Partners?

As an employee, you have access to a comprehensive benefits package including:

• Medical insurance – PPO, HMO & HSA
• 401k plan
• Employee Assistance Program
• Long-term disability
• Weekly payroll
• Online timecard approval

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.