Senior Research Associate Biologics/Bioconjugation

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 75,000 - 112,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Paid time off

Job summary

Vertex Pharmaceuticals seeks a Senior Research Associate in Biologics/Bioconjugation for its Boston lab. You will execute and optimize LNP conjugation and purification workflows, analyze quality attributes with DLS, Ribogreen, and HPLC, and document results for internal discussions.

Independence and initiative are valued in a fast-paced research environment. The role emphasizes hands-on bench work, collaboration with cross-functional teams, and contribution to IP-related materials.

Qualifications

• Bachelors in biological sciences with 4+ years' relevant experience or Masters with 0-2 years' experience.
• Hands-on experience in conjugation strategies and lab workflows.
• Experience with LNP characterization techniques (DLS, Ribogreen, HPLC).
• Experience with tangential flow filtration and sterile filtration preferred.
• Ability to interpret routine data and present results clearly.
• Ability to adapt experimental designs for improvement.
• Strong written and oral communication skills for internal reporting.

Responsibilities

• Execute routine conjugations of ligands, scaffolds, and peptides to LNPs using established methods.
• Develop, optimize, and troubleshoot tLNP conjugation and purification at bench and pilot scales.
• Analyze tLNP critical quality attributes using DLS, Ribogreen, and HPLC.
• Plan experiments and perform work with limited supervision; follow up on results.
• Maintain detailed records in ELNs and prepare summaries for internal discussions.
• Contribute to platform development documents and IP-related discussions.
• Maintain laboratory organization, supplies, and reagent inventories.

Skills

Conjugation strategies

LNP characterization

Tangential flow filtration

Data interpretation

Scientific communication

Education

Bachelor's in Biological Sciences

Master's degree or equivalent

Tools

DLS

RiboGreen assay

HPLC

TFF (Tangential Flow Filtration)

Job description

Senior Research Associate Biologics/Bioconjugation page is loaded## Senior Research Associate Biologics/Bioconjugationlocations: Boston, MAtime type: Full timeposted on: Posted Todayjob requisition id: REQ-30546**Job Description****General Summary:**Vertex is seeking a talented Senior Research Associate to join a collaborative research team focused on Biologics conjugation and optimization in Boston, MA. The group's mission is to deliver next generation biologics and genetic therapies impacting several therapeutic areas. We are looking for a candidate with a strong desire to support the development of targeted lipid nanoparticle (tLNP). In this *lab-based role*, ideal candidate will execute and improve laboratory workflows for lipid nanoparticle (LNP) conjugation and purification. The candidate should be independent, accustomed to taking initiative, and bring enthusiasm and intellectual curiosity to Vertex's fast-paced research environment.**Key Duties and Responsibilities:*** Execute routine conjugations of various ligands, scaffolds, and peptides to LNPs using established and emerging methods* Assist with the development, optimization, and troubleshooting of tLNP conjugation and purification processes at bench and pilot scales* Analyze tLNP critical quality attributes using techniques such as Dynamic Light Scattering (DLS), RiboGreen assays, HPLC, and related analytical methods* Participates in planning of experiments and may perform some experiments with limited supervision demonstrating responsible follow-up* Analyze experimental data, maintain detailed records in ELNs, and prepare summaries and presentations for internal team discussions* Contribute to technical discussions and documentation related to conjugation platform development and intellectual property* Maintain laboratory organization, supplies, and reagent inventories for the Bioconjugation team.**Knowledge and Skills:*** Hands on experience in various conjugation strategies. Preferred experience working in Antibody drug conjugates or Antibody oligonucleotide conjugation* Proficiency in LNP characterization techniques such as DLS, Ribogreen assay, and HPLC methods is preferred* Experience with tangential flow filtration (TFF) and sterile filtration preferred* Exhibits reliable ability to interpret routine, uncomplicated data* Applies technical knowledge to optimize some commonplace experimental procedures* Displays emerging ability to modify experimental designs and protocols to enable experimental and/or methodological improvement* Ability to present results in both oral and written reports**Education and Experience:*** Bachelors Degree in biological sciences and 4+ years of relevant employment experience or Masters Degree (or equivalent degree) and 0-2 years of experienceAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.**Pay Range:**$74,800 - $112,200**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**On-Site Designated**Flex Eligibility Status:**In this **On-Site** designated role, you will work **five days per week on-site** with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.#LI-Onsite**Company Information**Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]## **Help Us Achieve Our Mission**##*Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.**Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit**or follow us on* *,* *,* *,* *, and**We believe our culture is one of Vertex's greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.*