Senior Research Associate

TechDigital Group; Seattle (WA); On-site; USD 70,000 - 90,000; Full time

Job summary

TechDigital Group is recruiting for an associate in the LVV Platform Development team, focusing on the advancement of viral vector processes. Successful candidates will execute process development experiments in upstream and downstream settings and work collaboratively with multiple teams to accelerate client technologies.

Applicants should possess a STEM degree and ideally have hands-on experience in relevant biological or chemical engineering fields. Strong communication skills for reporting and team collaboration are crucial.

Qualifications

• 2+ years of relevant industry experience.
• Independently motivated with ability to work in teams.
• Ability to clearly articulate and document research.

Responsibilities

• Material generation of LVV for downstream processing.
• Execute and troubleshoot upstream and downstream experiments.
• Manage flow of samples and data analysis.

Skills

Suspension culture of mammalian cells

Process development experience

Viral vector development

Education

STEM degree

Tools

JMP for DoE design

Job description

Top Skills

• Experience with upstream processes intensification e.g. fed batch and perfusion development, process‑analytical technology (PAT)
• Experience with suspension culture of mammalian cells in shake flasks and small stirred tank bioreactors
• Experience with transfection‑based processes
• Experience in the development of viral vectors (e.g. adeno‑, retro‑, lenti‑), including successful transfer for GMP manufacturing

The associate will join the LVV Platform Development team working on vector biology and molecular optimization initiatives intended to drive next‑generation viral vector platform development. Specifically, in the pursuit of end‑to‑end assessment of client technologies and approaches, the associate will seek to become highly proficient in upstream production and downstream purification of lentiviral vectors, while gaining familiarity with LVV analytical methods and their interpretation in the context of LVV attributes and biology. The associate will also have the unique opportunity to be exposed to a wide range of highly client molecular designs, and to work collaboratively with a range of different groups doing different types of LVV development.

Responsibilities

• Material generation of LVV for downstream processing
• Execute and troubleshoot upstream and downstream process development experiments supporting next‑generation LVV production
• Manage the flow of samples and data and perform analyses
• Assist in the design of experiments and interpretation of data
• Provide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.)
• Support research‑to‑development transition endeavors, including early‑stage/pipeline molecular assessment activities
• Actively participate and support lab maintenance and continuous improvement initiatives
• Maintain accurate and detailed laboratory notebook and documentation
• Summarize and present data in group meetings and contribute to group discussions and team strategy
• Author technical reports and study memos

Basic Qualifications

• STEM degree with 2+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset
• Experience with suspension culture of mammalian cells in shake flasks and small stirred tank bioreactors
• Hands‑on experience in process development
• Independently motivated with ability to work in teams
• Ability to communicate clearly and concisely through oral presentation and technical writing
• Ability to leverage literature, internal and external resources to solve problems

Preferred Qualifications

• Degree in biological or chemical engineering, biochemistry, or bio‑related field
• Experience with JMP for DoE design and analysis
• Experience in the development of viral vectors (e.g. adeno‑, retro‑, lenti‑), including successful transfer for GMP manufacturing
• Experience with DSP operations
• Experience with upstream LVV optimization
• Experience with transfection‑based processes
• Experience with upstream processes intensification e.g. fed batch and perfusion development, process‑analytical technology (PAT)
• Experience with single‑use technologies