Senior Research Associate

Globalchannelmanagement; Boston (MA); Sur place; USD 80 000 - 110 000; Plein temps

Résumé du poste

Globalchannelmanagement seeks a Senior Research Associate (NGS) to lead RNA-seq, bulk, amplicon, and single-cell sequencing workflows. You will design and execute experiments to identify and validate novel targets, support QC, and document results in ELN systems.

Strong communication skills are required for presenting complex data clearly. The role requires 3–5 years of hands-on lab experience in molecular biology and NGS, with proficiency in Illumina platforms and multiple scRNA-seq methods.

Qualifications

• B.S. or M.S. in biological or biochemical sciences.
• 3–5 years of hands-on laboratory research experience required.
• Strong experience with RNA-seq and library prep workflows.

Responsabilités

• Lead RNA-seq, bulk, amplicon, and single-cell sequencing workflows.
• Design and execute experiments to identify drug targets.
• Support QC and data integrity across projects.
• Troubleshoot complex data anomalies to keep projects moving forward.
• Translate results into clear oral presentations and written reports.

Connaissances

RNA-seq

Amplicon-seq

Single-cell sequencing

qPCR

NGS library prep

Data QC

Experimental design

Formation

BS/MS in biological sciences

Outils

10X Genomics Chromium

Illumina PIP-seq

ScaleBio

Parse Biosciences

Electronic lab notebook

Description du poste

Senior Research Associate – Next-Generation Sequencing (NGS) needs 3–5 years of bench experience falls dire

• End-to-End Library Prep:Lead RNA-seq, bulk, amplicon, and highly specialized single-cell (scRNA-seq) and single-nucleus (snRNA-seq) sequencing workflows.
• Target Identification: Design and execute molecular and cell biology experiments to identify and validate novel drug targets.
• Assay Optimization:Support assay design, optimization, validation, and complex data quality control (QC).
• Troubleshooting: Diagnose and resolve complex technical data anomalies to keep drug discovery projects moving forward.
• Collaborative Reporting:Translate complex experimental results into clear oral presentations and written documentation.
• Education & Experience:B.S. and/or M.S. in biological or biochemical sciences with 3–5 years of hands‑on laboratory research experience.
• Molecular Biology Mastery:Proven expertise in nucleic acid extraction, purification, quantification, qPCR, and NGS library prep/QC.
• Advanced Sequencing Background:Deep understanding of NGS technologies and data QC (preferably Illumina), with direct experience in bulk RNA-seq and amplicon-seq.
• Single-Cell Expertise:Direct experience with scRNA-seq and snRNA-seq library preparation is required. You must be familiar with multiple platforms (e.g., 10X Genomics Chromium, Illumina PIP‑seq, ScaleBio, or Parse Biosciences).
• Operational Excellence:Experience documenting experiments in electronic notebook software, alongside exceptional organizational and time‑management skills.

Preferred Extras (A Plus, But Not Required)

• Familiarity with CRISPR-based gene editing and high-throughput screening.
• Experience operating lab automation equipment (Mantis, Integra systems, liquid handlers, SPTLabtech Firefly, Tecan, etc.).