Senior Program Manager, AI-Driven Cross-Functional Programs

Ohalo; San Francisco (CA); On-site; USD 180,000 - 220,000; Full time

Job summary

Ohalo in South San Francisco is seeking a Senior Program Manager to lead cross-functional programs spanning Biotech R&D, engineering and operations. You will own outcomes, set strategy, and drive delivery from concept to execution.

You will use AI as a force multiplier, build scalable processes, manage budgets and timelines, and translate complex science into clear updates for scientists and the board.

Qualifications

• 8+ years of experience leading cross-functional programs in R&D, Engineering, technology, operations, or a related field.
• Strong engineering fundamentals, with experience taking technical work from design through deployment.
• Hands-on with AI and eager to go further: you use AI tools in your daily work and want to build apps and agents that run work continuously, not just one-off analyses or reports.
• Strong systems thinker. Comfortable working across disciplines and turning ambiguity into executable plans.
• Track record of leading cross-functional teams and delivering on timelines and commitments.
• Proven ability to influence without authority and build alignment between technical and non-technical stakeholders.
• High-ownership leader who is energized by mission-driven work and follows through.
• First-principles thinker who questions "how it’s always been done" and isn’t afraid to redesign a process.
• A Bachelor’s degree is required, ideally in a technical discipline. An advanced degree is preferred
• Experience in a scientific, technical, or engineering environment is required.

Responsibilities

• Own program success for one or more strategic, cross-functional programs.
• Design and implement scalable processes and methods for planning, execution, and tracking.
• Drive alignment with stakeholders and executive leadership. own decisions, escalations, and accountability.
• Own budgeting, forecasting, and analytics of managed programs.
• Build and maintain integrated program plans that connect workstreams across teams. Make dependencies and critical paths explicit, and manage them.
• Define how each program fits together: workstreams, interfaces, handoffs, and validation. Keep teams executing to one integrated schedule.
• Make the call on trade-offs and escalations; drive alignment across scientists, operators, and executive leadership without waiting for consensus.
• Spot bottlenecks early and unblock teams through clear priorities and fast follow-through.
• Translate technical complexity into clear artifacts for audiences ranging from scientists to Ohalo’s board.
• Use AI as a force multiplier that runs program work, continuously (tracking, reporting, follow-ups), not one-off analyses or reports. Hold a high bar for accuracy and traceability.
• Hold the team to the same standard and help each member build AI into how they work.

Skills

Cross-functional leadership

Systems thinker

AI tools usage

Program management

Stakeholder alignment

High-ownership

First-principles thinking

Leadership

Education

Bachelor’s degree in a technical discipline

Advanced degree preferred

Job description

Ohalo in South San Francisco is seeking a Senior Program Manager to lead cross-functional programs spanning Biotech R&D, engineering and operations. You will own outcomes, set strategy, and drive delivery from concept to execution.

You will use AI as a force multiplier, build scalable processes, manage budgets and timelines, and translate complex science into clear updates for scientists and the board.