Senior Principal Translational Toxicologist

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 173,000 - 322,000; Full time

Job summary

Genentech in South San Francisco, CA is seeking a Senior Principal Scientist to lead translational safety across multiple development programs, including novel modalities. The role requires integrating toxicology, pathology, pharmacology, translational and clinical data to inform risk, strategy and regulatory readiness.

You will design safety programs, synthesize data into weight‑of‑evidence decisions, mentor scientists, and represent Translational Safety in interactions with health authorities

Qualifications

• PhD and post‑doctorate or equivalent in toxicology or a relevant field with 8+ years in pharma/biotech/CRO.

Responsibilities

• Lead safety assessment for multiple development programs across modalities.
• Synthesize data into weight‑of‑evidence decisions to inform risk and regulatory strategy.
• Mentor toxicologists and scientists; interact with health authorities and cross‑functional teams.

Job description

Genentech in South San Francisco, CA is seeking a Senior Principal Scientist to lead translational safety across multiple development programs, including novel modalities. The role requires integrating toxicology, pathology, pharmacology, translational and clinical data to inform risk, strategy and regulatory readiness.

You will design safety programs, synthesize data into weight‑of‑evidence decisions, mentor scientists, and represent Translational Safety in interactions with health authorities