Senior Principal Systems Engineer, NGS Platform

F. Hoffmann-La Roche AG; Santa Clara, Northern (CA, KY); Hybrid; USD 127,000 - 237,000; Full time

Job summary

Roche in Santa Clara, CA seeks a Principal Systems Engineer II to lead cross-functional V&V for next-generation sequencing platforms. You will guide verification campaigns across hardware, software, firmware, and chemistry interfaces, and drive AI-assisted test generation. Collaboration with Quality, Regulatory, and Operations is essential.

The role demands hands-on systems engineering mastery, risk assessment, and mentoring of junior engineers, with a hybrid work arrangement in Santa Clara.

Qualifications

• 10+ years of related experience in systems engineering or a direct discipline
• Experience leading full-scale verification campaigns in complex medical devices
• Experience with NGS platforms, molecular diagnostics, or nucleic acid technologies

Responsibilities

• Lead cross-functional Verification & Validation (V&V) campaigns for complex NGS platforms
• Draft, review, and execute test cases; drive AI-driven test generation
• Evaluate design concepts for requirements coverage and risk
• Serve as primary technical escalation point for complex issues
• Mentor junior systems engineers and influence Quality, Regulatory, Operations teams
• Oversee environmental chamber studies and hardware compliance testing (EMC/EMI)

Skills

V&V leadership

Systems engineering

Cross-functional coordination

AI-assisted testing

Troubleshooting

Education

MS degree in a related discipline

PhD degree in a related discipline

10+ years related experience

Tools

HPALM

RETINA

Job description

Roche in Santa Clara, CA seeks a Principal Systems Engineer II to lead cross-functional V&V for next-generation sequencing platforms. You will guide verification campaigns across hardware, software, firmware, and chemistry interfaces, and drive AI-assisted test generation. Collaboration with Quality, Regulatory, and Operations is essential.

The role demands hands-on systems engineering mastery, risk assessment, and mentoring of junior engineers, with a hybrid work arrangement in Santa Clara.