Senior Principal Scientist, Veterinary Pathology Board Certified

Scorpion Therapeutics; Pennsylvania; Hybrid; USD 180,000 - 280,000; Full time

Job summary

Scorpion Therapeutics in the United States seeks a senior pathologist to lead nonclinical safety programs, oversee study design, and guide regulatory communications. The role emphasizes histomorphology, toxicology, and collaboration with immunology and translational teams. A DVM with residency and ACVP/ECVP certification is preferred; a PhD is a plus. Hybrid work model.

Leading safety assessments, designing studies, and mentoring teams will be core responsibilities in this role.

Qualifications

• Must have a DVM degree; ACVP/ECVP board certification preferred.
• Residency in anatomic/toxicologic pathology.
• Experience leading toxicology and safety pharmacology efforts.

Responsibilities

• Lead nonclinical safety characterization and data interpretation.
• Design experiments to advance programs and assess human relevance.
• Provide scientific leadership with toxicology, safety pharmacology, and translational teams.
• Utilize on-site histology, in vitro/in vivo assays, and digital image analysis.
• Develop biomarkers and predictive models to reduce safety risks.
• Oversee study design/execution and regulatory communications with global agencies.
• Collaborate across cross-pathologist teams in a hybrid work setting.

Skills

Collaborative spirit

Drug development

Histopathology

Immunochemistry

Immunology research

In vivo models

Toxicology pathology

Veterinary pathology

Postmortem analysis

Innovation

Lab processes

Pathogenesis

Education

DVM

PhD in Immunology/Toxicology/Pathology

Job description

Key Responsibilities:

• Employ routine H&E evaluations and other specialized techniques to characterize the safety profile of new drugs from toxicology and investigative studies.
• Independently analyze data, interpret postmortem results significance, review literature, and design experiments to solve scientific problems and advance programs.
• Provide scientific leadership with toxicology, safety pharmacology, and translational teams to define mechanisms of toxicity, assess human relevance, and guide risk mitigation strategies (including immunology and biologics).
• Utilize on-site tools including in vitro/in vivo assays, historical controls slide archive/database, digital pathology, transmission electron microscopy, immunohistochemistry, in situ hybridization, and quantitative digital image analysis with targeted machine learning.
• Develop novel biomarkers and predictive models to reduce safety-related risks.
• Serve as nonclinical drug safety department lead on drug development teams: oversee study design/execution and generate regulatory strategy and communications with global regulatory agencies.
• Work in a hybrid environment with cross-pathologist collaboration and knowledge sharing.

Minimum Education Required:

• Doctor of Veterinary Medicine (DVM)

Preferred:

• PhD in Immunology, Toxicology, Pathology, or related discipline

Required Experience and Skills:

• 10+ years as a pathologist in biotech, pharma, or a CRO.
• Demonstrated proficiency in histomorphologic evaluation and interpretation of toxicology studies.
• Residency in anatomic/toxicologic pathology.
• ACVP or ECVP-board certification (or equivalent) in anatomic pathology.
• Strong collaborative communication across cross-functional teams.

Preferred Experience and Skills:

• Knowledge of drug discovery/development/regulatory processes; experience on drug development project teams.
• Experience supporting immunology/biologics programs.
• Experience as pathology lead or external due diligence subject-matter expert.
• Enterprise-level scientific leadership, cross-program influence, mentoring/management.

Required Skills:

• Collaborative spirit; drug development/discovery; histopathology; immunochemistry; immunology research; in vivo models; toxicology/toxicological pathology; veterinary pathology; postmortem analysis; innovation; laboratory processes; pathogenesis.