Senior Principal Scientist, Type 2 Immunology

Sanofi; Cambridge (MA); On-site; USD 149,000 - 215,000; Full time

Job summary

Sanofi is seeking a Senior Principal Scientist in Cambridge, MA to lead preclinical immunology programs and shape translational strategies that inform clinical development and lifecycle management.

You will drive collaborations with Development, Medical Affairs, and Commercial teams, mentor junior scientists, and integrate clinical insights back into research to maximize portfolio value. This role blends bench science with strategic leadership at Sanofi.

Qualifications

• PhD in Immunology, neuroimmunology, molecular biology, pharmacology or related field with 8+ years experience in academia or biopharma.
• Or equivalent: Master’s +10 years; Bachelor’s +12 years.
• Demonstrated experience leading preclinical research or contributing to early clinical and/or late-stage programs.

Responsibilities

• Lead preclinical research programs from hypothesis generation through execution, integrating findings into clinical strategy.
• Support early clinical and/or late-stage or marketed product programs, translating clinical insights back to research.
• Design and execute research with Development, Medical Affairs, and Commercial teams as part of IEGP to maximize portfolio value.
• Formulate hypotheses and apply expertise to design experiments in murine and human immunology.
• Develop in vitro and in vivo assays and apply single-cell, multiomic, and imaging technologies.
• Lead cross-functional collaborations and manage stakeholder relationships across a global matrixed organization.
• Communicate findings clearly to technical and non-technical audiences.
• Mentor junior scientists and support their development.
• Stay at forefront of science and contribute to group strategy.
• Maintain lab activity with bench work as needed and ensure safety and compliance.

Skills

Immunology expertise

Translational research

Preclinical leadership

Cross-functional collaboration

Education

PhD in Immunology or related field

Tools

Flow cytometry

scRNA-seq

Multiomics

Job description

Job title: Senior Principal Scientist Type 2 Immunology Location: Cambridge, MA

About the Job Immunology and Inflammation Therapeutic Area We have an exciting opportunity to join Sanofi's Translational Biology team as a Senior Principal Scientist within the Type 2 Immunology cluster.

This role sits at the intersection of cutting-edge preclinical research and clinical development, offering a unique platform to shape the trajectory of one of the industry's most compelling immunology portfolios.

Working at our Cambridge Crossing research campus, you will contribute to a team with deep commitment to scientific excellence and patient impact across dermatology, gastroenterology, respiratory, and rheumatology.

This position carries a dual mandate. Leading preclinical research programs from hypothesis generation through execution, while also serving as to support early clinical and/or late-stage or marketed product programs.

In this capacity, you will drive translational research strategies that inform clinical development and support lifecycle management initiatives for assets.

You will integrate insights from clinical studies back into research strategy, ensuring a continuous and productive dialogue between both early research, clinical development and medical affairs.

The successful candidate will leverage Sanofi's extensive technical capabilities, including AI enabled platforms, single cell technologies, and multiomic approaches, while collaborating closely with Development, Medical Affairs, and Commercial teams.

This is an opportunity to make a meaningful scientific and strategic contribution within a highly collaborative, cross functional environment.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research.

In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth.

Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world.

Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

• Lead preclinical research programs from hypothesis generation through experimental execution, integrating findings into broader clinical strategy.
• Directly support early clinical and or late stage or marketed product programs, translating clinical insights back to research and driving translational strategies to support clinical decision making and asset life cycle management.
• Design and execute research programs in close partnership with Development, Medical Affairs, and Commercial teams as part of IEGP to maximize the value of Sanofi's portfolio.
• Independently formulate research hypotheses and apply scientific expertise to design and execute experiments using murine and human immunology approaches.
• Develop novel in vitro and in vivo assays and apply advanced technologies including single cell approaches (flow cytometry, scRNAseq), multiomics, and imaging platforms.
• Lead cross functional collaborations and manage stakeholder relationships effectively across a matrixed global organization.
• Communicate research findings clearly and compellingly to diverse audiences, both technical and nontechnical, internal and external.
• Mentor and actively support the scientific and professional development of junior team members.
• Stay at the forefront of scientific advances and contribute to the strategic direction of the group.
• Maintain laboratory activity while providing scientific leadership; this role has an expectation of bench engagement as necessary.
• Ensure adherence to safety standards, laboratory conduct, diligent ELN record keeping and Sanofi's code of conduct.

About You

Basic Qualifications: PhD in Immunology, neuroimmunology, molecular biology, pharmacology or related fields with 8+ years of relevant experience in an academic or biopharmaceutical setting. Or equivalent: Master's + 10 years of experience; Bachelor's + 12 years of experience). Demonstrated experience leading preclinical research projects or key contributor on early clinical and/or late-stage or marketed product programs, this is a critical requirement for this role Proven track record in translational research supporting clinical development and/or lifecycle management Strong expertise in human and murine immunology and inflammatory disease pathways Experience with advanced technologies including single cell approaches (flow cytometry, scRNA-seq), molecular techniques, and multi-omic platforms Proven ability to work collaboratively in cross-functional, matrixed environments with Development, Medical Affairs, and/or Commercial teams Excellent stakeholder management and communication skills across diverse audiences Strong team player with a collaborative mindset and genuine commitment to supporting others Demonstrated mentorship capabilities and track record of developing junior scientists Record of scientific publications and presentations in high impact peer-reviewed journals Experience with external academic collaborations and working with CRO

Preferred Qualifications

Direct experience in Type 2 inflammatory diseases (dermatology, respiratory, GI, rheumatology) Experience with clinical biomarker strategy development and implementation Hands-on experience with human tissue biopsies (skin, lung, gut), mouse disease models, and or organoid systems Experience contributing to regulatory submissions or clinical trial design

Why Choose Us?

Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. Help improve the lives of millions of people globally by making drug development quicker and more effective. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SA #LI-SA #LI-Onsite #vhd

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US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

North America Applicants Only

The salary range for this position is: $148,500.00 - $214,500.00 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

We are an R&D driven, AI-powered biopharma company committed to improving people’s lives and creating compelling growth. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives. We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world. Discover more about us visiting www.sanofi.com or via our movie

We are Sanofi Start a career that makes a difference. Reinvention is in our DNA. It’s what drove our evolution from a small French enterprise to one of the world’s leading biopharma companies. Whether it’s using AI to shorten drug-discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities. This is where you grow your career. We open the door for you to explore new opportunities, push your limits, and connect with people who are driven by a shared purpose: we chase the miracles of science to improve people’s lives.