Senior/Principal Scientist, Medicinal Chemistry – Peptide Drug Design

Bazeta; United States; Remote; USD 150,000 - 210,000; Full time

Benefits offered by this job

Competitive compensation

Equity

Comprehensive benefits

Job summary

Newbridge is seeking a Senior/Principal Scientist in Medicinal Chemistry to lead peptide drug design from concept to candidate. You will own the chemistry strategy for first-in-class programs and collaborate with AI/ML, CADD, biology, and translational teams to compress timelines from idea to IND.

The role requires a PhD and 8+ years in pharma, with peptides/proteins advanced to IND/clinic. The team is distributed across the US and China, offering startup velocity with ownership and equity.

Qualifications

• PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or related field.
• 8+ years industry experience in major U.S. pharma companies with peptides/proteins advanced to IND/clinic.
• Startup experience: thrive in agile, ownership-driven environments.

Responsibilities

• Lead design and optimization of First-in-Class peptide therapeutics against novel, high-value targets.
• Drive SAR campaigns across macrocycles, stapled peptides, and peptide-drug conjugates.
• Partner with AI/ML, CADD, structural biology, DMPK, and pharmacology for rapid cycles.
• Advance programs through hit-to-lead, lead optimization, and IND-enabling studies.
• Represent Medicinal Chemistry on core project teams and mentor junior scientists.

Skills

Peptide design

SBDD

Lead mentoring

IND/clinic experience

Agile/startup environment

Education

PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or related field

Tools

AI/ML collaboration

CADD

Structural biology

Job description

# Senior/Principal Scientist, Medicinal Chemistry – Peptide Drug DesignUnited States35 minutes agoID 4369589Price on request## DetailsEmployment type: Full-timeRemote: YesCompany: Newbridge## DescriptionGot it — here's a version with Our Client written out and ready to drop your client's name/branding in. Just replace [Our Client] and the bracketed details. Senior/Principal Scientist, Medicinal Chemistry – Peptide Drug Design Level: Senior Scientist to Associate Director | ByteDance 3-1 / 3-2 Equivalent Location: Flexible – United States or China About Our Client Our Client is a clinical-stage biotech company redefining peptide therapeutics through the integration of AI-driven design, novel chemistry, and translational biology. Backed by [top-tier investors/partners], we are advancing a pipeline of First-in-Class (FIC) programs targeting [oncology, metabolic, immunology — insert TAs] with high unmet need. We combine the scientific rigor of Big Pharma with the speed and ownership of a startup. Our team is distributed across the US and China, united by one goal: deliver breakthrough medicines to patients, faster. The Role We are seeking a Senior or Principal Scientist / Associate Director in Medicinal Chemistry to lead peptide drug discovery from concept to candidate. You will own the chemistry strategy for FIC programs and work shoulder-to-shoulder with computational, biology, and translational teams to compress timelines from idea to IND. What You'll Own • Lead design and optimization of First-in-Class peptide therapeutics against novel, high-value targets • Drive SAR campaigns across macrocycles, stapled peptides, peptide-drug conjugates, and oral bioavailable peptides • Partner with AI/ML, CADD, structural biology, DMPK, and pharmacology to run rapid design-make-test cycles • Advance programs through hit-to-lead, lead optimization, and IND-enabling studies • Represent Medicinal Chemistry on core project teams and mentor junior scientists What You Bring • PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or related field • 8+ years industry experience at major U.S. pharmaceutical companies , with peptides/proteins taken to IND/clinic • Startup experience : Thrive in agile, ambiguous environments with high ownership and urgency • ByteDance Level 3-1 to 3-2 equivalent — Senior Scientist, Principal Scientist, or Associate Director scope • Deep expertise in peptide design: non-canonical amino acids, cyclization, conjugation, SBDD, and peptide property optimization • Proven FIC track record : Invented novel mechanisms of action and advanced them into development Why Join Our Client • Real shots on goal : Work on FIC programs with line of sight to patients • Speed + Resources : Startup velocity, backed to move programs to the clinic • Global + Flexible : Base in US or China, collaborate with world-class talent • Top-tier package : Competitive comp, significant equity, and comprehensive benefits Originally posted on Himalayas Source: Himalayas (https://himalayas.app/companies/newbridge/jobs/senior-principal-scientist-medicinal-chemistry-peptide-drug-design-6338002115?utm\\_source=api)This listing comes from a partner feed. Apply on the source website.