Scientist, Product Biochemistry

BioSpace; Village of Tarrytown (NY); On-site; USD 94,000 - 153,000; Full time

Job summary

Regeneron is seeking an experienced Scientist to join the Product Biochemistry team, supporting preparation and characterization of critical reagents for preclinical and regulated assay development. You will generate well-characterized, fit-for-purpose reagents and perform stability studies in a fast-paced environment.

Location is on-site in Tarrytown, NY, with full-time shift requirements. The role involves analytical testing (SDS-PAGE, Western blot, CE-SDS, SEC, ELISA) and close collaboration

Qualifications

• BS/MS with 8+ years (BS) or 6+ years (MS) of industry experience.
• Hands-on protein characterization, purification, and conjugation.
• Experience with SDS-PAGE, Western blot, CE-SDS, SEC, UV-Vis.
• Knowledge of protein stability, aggregation, and modification effects.

Responsibilities

• Characterize identity, purity, stability, aggregation and binding properties of reagents.
• Prepare, purify and conjugate critical protein/biomolecule reagents for assay development.
• Perform routine/advanced protein analytical testing (SDS-PAGE, CE-SDS, SEC, ELISA, UV-Vis).
• Document procedures and results in electronic lab notebook; present findings.
• Maintain laboratory instrumentation for purification and characterization.
• Collaborate with cross-functional teams to meet project timelines.
• Troubleshoot methods and instrumentation; support reagent lifecycle and validation.

Skills

Protein characterization

Purification

Conjugation

SDS-PAGE

Western blot

CE-SDS

SEC

UV-Vis spectroscopy

Data documentation

GxP/GLP knowledge

Education

BS in Biochemistry/Biophysics/Engineering

MS in Biochemistry/Biophysics/Engineering

Tools

Empower

UNICORN

FPLC systems

Job description

Build Our Future Together

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking an experienced and highly motivated Scientist to join the Product Biochemistry team, supporting the preparation and characterization of critical protein and biomolecule reagents used in preclinical and regulated assay development. In this role, you will support the generation of well-characterized, fit-for-purpose reagents, perform stability and characterization studies, and work closely with cross-functional teams to meet project and assay-development timelines.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & Where

Shift Requirements: Full-time

Location: On-site in Tarrytown, NY

Discover Your Role

• Perform comprehensive reagent characterization to evaluate identity, purity, stability, aggregation, binding properties, labeling efficiency, and overall fitness for intended use
• Support the preparation, purification, and conjugation of critical protein and biomolecule reagents for use in assay development and testing
• Conduct routine and advanced protein analytical testing using techniques such as SDS-PAGE, Western blot, CE-SDS, SEC, UV-Vis spectroscopy, ELISA, and other protein characterization methods
• Support stability characterization of critical reagents, including appropriate stability and freeze/thaw studies, and investigate factors affecting reagent stability and assay performance
• Contribute to the development and implementation of new analytical approaches and improved characterization strategies for critical reagents
• Troubleshoot reagent quality, analytical methods, and instrumentation, and contribute to scientific problem-solving
• Accurately document experimental procedures, analytical results, and conclusions in the electronic laboratory notebook according to established procedures and timelines
• Summarize experimental results in clear technical reports and presentations, and communicate findings at group and project meetings
• Maintain and support laboratory instrumentation used for protein purification and characterization
• Work collaboratively with cross-functional teams to coordinate reagent needs, priorities, and deliverables, and support project timelines
• Manage multiple reagent requests and characterization activities simultaneously while maintaining high standards for scientific quality and documentation

This Role Requires

• BS/MS in Biochemistry, Biophysics, Engineering, or a related field, with BS and 8+ years or MS and 6+ years of relevant industry experience
• Strong hands-on experience in protein characterization, purification, and conjugation
• Demonstrated experience with multiple protein analytical techniques such as SDS-PAGE, Western blot, CE-SDS, SEC, UV-Vis spectroscopy, and IEF/cIEF
• Experience with protein purification techniques including affinity chromatography, ion exchange chromatography, size-exclusion chromatography, and FPLC systems
• Strong understanding of fundamental protein biochemistry, including protein stability, aggregation, binding interactions, and the potential impact of chemical modification on protein properties
• Strong laboratory documentation, data organization, and record-keeping skills
• Demonstrated ability to organize and prioritize multiple projects and deliverables in a fast-paced research environment
• Strong problem-solving skills with the ability to work independently with appropriate guidance
• Strong team player with demonstrated ability to collaborate effectively across scientific and functional groups
• Excellent verbal and written communication skills
• Experience with protein labeling/conjugation, including biotin, fluorescent dyes, ruthenium, or related protein modifications, is a plus
• Experience with SPR/BLI-based binding characterization is a plus
• Experience with additional biophysical or analytical methods such as LC-MS, MALDI-TOF MS, SEC-MALS, DLS, or DSC is a plus
• Experience with Empower, UNICORN, or similar chromatography/data-analysis software is a plus
• Experience supporting critical reagents used in bioanalytical, potency, or other regulated assays is a plus
• Familiarity with GxP/GLP laboratory practices, controlled documentation, and reagent lifecycle/stability activities is a plus

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Please be advised that at Regeneron, we believe we do our best work when we are together.

For that reason, many roles are required to be performed onsite.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Salary Range (annually)

$93,900.00 - $153,300.00

For other locations, additional information will be provided during the recruitment process.