Senior/Principal Research Scientist - Assays, Therapeutic Proteins and AI

Umbilical Life; New York (NY); On-site; USD 80,000 - 120,000; Full time

Job summary

An innovative firm is seeking a skilled professional in Protein Sciences with a focus on Assay Development technologies. This role emphasizes the application of AI and Dry Lab technologies to enhance wet lab assay development. The ideal candidate will possess a PhD in a relevant field and have a strong background in protein sciences, coupled with expertise in assay design and development. You will engage in a fast-paced environment, working cross-functionally to optimize lab-based assays and contribute to hit and lead identification. If you're passionate about leveraging cutting-edge technologies in drug discovery, this opportunity is for you.

Qualifications

• PhD in biochemistry or biophysics with 2 years of industry experience.
• Strong assay design skills for protein hit identification.

Responsibilities

• Design and run assays to confirm and optimize AI-generated hits.
• Investigate mechanism of action and contribute to target optimization.

Skills

Assay Development

AI/ML Application

Biochemical/Biophysical Assays

Structural Activity Relationships (SAR)

Data Analysis

Education

PhD in Biochemistry

PhD in Biophysics

Tools

SPR

DSF

Lab Automation

Job description

My client is an expertProtein Sciences, Early Drug Discoverygroup looking to identify an expert inAssay Development technologiesapplied totherapeutic proteinswith atranslational focuson leveragingAI and dry lab technologiestoenhance wet lab assay development.

The key need for this position is [Therapeutic ProteinsxAssay DevelopmentxAI/Dry Lab]

The individual will have a solid background inprotein sciences in drug discovery, with a secondary specialization in applying (not developing)AI/MLandDry Lab technologies,tooptimize Lab-based assay development.

Responsibilities

• Design and run biochemical/biophysical assays to confirm, qualify, and optimize AI-generated hits, including binding affinities and site specificity.
• Investigate mechanism of action.
• Contribute to hit/lead identification and optimization for new targets and modalities.
• Work cross-functionally in a fast-paced, translational environment with exceptional ability to communicate across teams, and stakeholders.

Profile (Essential)

• PhD in biochemistry, biophysics, or related field + 2 years industry experience.
• Strongassay design & developmentskills for protein hit ID and qualification.
• Experience withmulti-modal approaches(e.g., enzyme modulation, targeted degradation).
• Proficient inlabeled and label-free assays(e.g., SPR, DSF and more).
• Holistic and solid understanding ofStructural activity relationships(SAR) & proteins (and their principals;kinetics, thermodynamics,andconformational dynamicsin drug discovery).
• Experience with Dry Lab technologies -Applying AI/ML, data analysis, lab automation, and structural biology.

Questions?

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