Senior MES Engineer

Orise; Raleigh (NC); On-site; USD 120,000 - 160,000; Full time

Job summary

Orise is seeking a Senior MES Engineer to expand our Manufacturing Execution Systems practice and provide on-site engineering support for pharmaceutical manufacturing in the RTP area. You will lead MES design, configuration, and deployment, acting as a technical SME for MES platforms while collaborating with production, quality, and IT stakeholders.

The role covers MES lifecycle activities from requirements gathering through deployment and support, including change management, investigations,

Qualifications

• Bachelor’s degree in Engineering, Computer Science, Information Systems, or a related technical discipline.
• 7+ years of experience supporting or implementing MES solutions in pharmaceutical, biotech, or life sciences manufacturing environments.
• Strong knowledge of GMP regulations, data integrity principles, and validated systems.
• Hands-on experience with MES platforms (e.g., Emerson Syncade, Rockwell PharmaSuite, Körber PAS-X or similar).
• Experience with MES configuration, integration, and support across manufacturing operations.
• Strong troubleshooting, analytical, and problem-solving skills.
• Ability to work effectively in an on-site, client-facing role.
• Excellent written and verbal communication skills.

Responsibilities

• Provide on-site and remote MES engineering support for pharmaceutical manufacturing operations in GMP environments.
• Lead the design, configuration, and deployment of MES solutions in GMP-regulated environments.
• Serve as a technical subject matter expert for MES platforms, supporting production, quality, and IT stakeholders.
• Support MES lifecycle activities including requirements gathering, system configuration, testing, validation, deployment, and operational support.
• Lead or contribute to change management, impact assessments, and controlled system updates.
• Support investigations, root cause analysis, and issue resolution related to MES applications.
• Lead, mentor, and grow a team of MES engineers, providing hands-on technical guidance, career development support, and day-to-day leadership to build a strong and scalable MES practice.
• Drive the continued growth of the MES practice by defining standards, establishing best practices, and providing technical leadership to ensure consistent, high-quality MES solution delivery.
• Collaborate closely with Sales and Business Development to support pre-sales activities, shape MES solutions, and identify new opportunities that expand the MES practice and overall business.

Skills

GMP regulations

Data integrity

Analytical thinking

Troubleshooting

Problem-solving

Written and verbal communication

On-site client-facing

Education

Bachelor’s degree in Engineering, Computer Science, Information Systems, or related technical discipline

7+ years experience in MES support/implementation (pharma/biotech/life sciences)

Tools

Emerson Syncade

Rockwell PharmaSuite

Körber PAS-X

Job description

Your Responsibilities We are seeking a Senior MES Engineer to support the expansion of our Manufacturing Execution Systems (MES) practice and provide on-site engineering support for pharmaceutical manufacturing operations in the RTP area, including.

This role will serve as a technical leader, delivering MES solutions that support manufacturing efficiency, data integrity, and regulatory compliance in GMP environments.

Key Responsibilities

• Provide on-site and remote MES engineering support for pharmaceutical manufacturing operations
• Lead the design, configuration, and deployment of MES solutions in GMP-regulated environments
• Serve as a technical subject matter expert for MES platforms, supporting production, quality, and IT stakeholders
• Support MES lifecycle activities including requirements gathering, system configuration, testing, validation, deployment, and operational support
• Lead or contribute to change management, impact assessments, and controlled system updates
• Support investigations, root cause analysis, and issue resolution related to MES applications
• Lead, mentor, and grow a team of MES engineers, providing hands-on technical guidance, career development support, and day-to-day leadership to build a strong and scalable MES practice
• Drive the continued growth of the MES practice by defining standards, establishing best practices, and providing technical leadership to ensure consistent, high-quality MES solution delivery
• Contribute to the growth of the MES practice through standardization, best practices, and technical leadership
• Collaborate closely with Sales and Business Development to support pre-sales activities, shape MES solutions, and identify new opportunities that expand the MES practice and overall business

Your profile

• Bachelor’s degree in Engineering, Computer Science, Information Systems, or a related technical discipline
• 7+ years of experience supporting or implementing MES solutions in pharmaceutical, biotech, or life sciences manufacturing environments
• Strong knowledge of GMP regulations, data integrity principles, and validated systems
• Hands-on experience with one or more MES platforms (e.g., Emerson Syncade, Rockwell PharmaSuite, Körber PAS-X, or similar)
• Experience with MES configuration, integration, and support across manufacturing operations
• Strong troubleshooting, analytical, and problem-solving skills
• Ability to work effectively in an on-site, client-façing role
• Excellent written and verbal communication skills

Disclaimer on the Use of AI in our Recruitment Process

To ensure our hiring process is fair, ethical, and transparent, ATS incorporates the use of AI technologies to enhance the recruitment process. We utilize Microsoft CoPilot to assist with the development and posting of job descriptions and assist with recruitment administrative tasks. The software uses pre-defined, rule-based filters which operate on fixed criteria and do not perform autonomous evaluation or generate independent recommendations. Microsoft Team Transcript is used to capture and document candidate interviews. Prior to the start of any interview, you will be asked if you consent to the use of transcript. The decision is yours and it will be honored by ATS.

The use of AI within our recruitment process is governed by the following core principles:

• Human Oversight and Accountability – AI is used solely to augment, not replace human judgment. All decisions regarding CV/resume screening, who to interview, and who to hire are made by ATS hiring managers and recruitment teams.
• Transparency and Data Protection – ATS will inform candidates when AI is being used to transcribe an interview to ensure our notes are complete and accurate. Candidates may choose whether or not to allow the use of transcript. All applicant data, including AI-generated interview notes, is treated as a confidential recruitment record and managed in accordance with applicable data protection laws.
• Fairness and Equality – ATS is committed to ensuring the use of AI is vetted and assessed to ensure it is not creating or perpetuating bias or discrimination.