Senior Medicinal Chemist, Peptide & Macrocycle Discovery

Psivant Therapeutics, Inc.; Massachusetts; On-site; USD 120,000 - 190,000; Full time

Benefits offered by this job

401k match

Competitive salary

Job summary

Psivant Therapeutics, Inc. is seeking a medicinal chemist to advance peptide therapeutics and small molecule programs from hit identification to development candidate nomination.

The role blends synthetic and medicinal chemistry with computational drug design to optimize potency, stability, and pharmacokinetic properties for oral administration. The candidate will lead a growing medicinal chemistry team, collaborating across computational chemistry, biophysics, structural biology, and biology,

Qualifications

• Education in organic or medicinal chemistry at BS, MS or PhD level.
• Experience advancing molecules from hit to development candidate.
• Proficiency in peptide and small molecule design and synthesis.

Responsibilities

• Advance peptide therapeutics and small molecule programs from screening to development candidate selection.
• Lead cross-functional collaboration with CADD, biophysics, structural biology, DMPK and biology teams.
• Guide CRO chemists to deliver complex targets for testing.

Skills

Macrocyclic peptides

Peptide synthesis

Medicinal chemistry

Computational modeling

AI in drug discovery

External CRO management

Communication

Education

BS/MS/PhD in organic or medicinal chemistry

Tools

Spotfire

Job description

Psivant Therapeutics, Inc. is seeking a medicinal chemist to advance peptide therapeutics and small molecule programs from hit identification to development candidate nomination.

The role blends synthetic and medicinal chemistry with computational drug design to optimize potency, stability, and pharmacokinetic properties for oral administration. The candidate will lead a growing medicinal chemistry team, collaborating across computational chemistry, biophysics, structural biology, and biology,