Senior Medicinal Chemist, AI-Driven Drug Discovery

Axiom Bio; San Francisco (CA); On-site; USD 180,000 - 280,000; Full time

Job summary

Axiom is seeking exceptional drug discovery scientists with strong computational and mathematical instincts to help build our ecosystem. You will work directly with scientists at top pharma/biotech, researchers from leading AI labs, and Axiom’s multidisciplinary team to build experimental datasets, agentic systems, and product capabilities needed to predict human drug outcomes.

They will deploy these agents into real discovery workflows to inform go/no-go decisions on high-value programs.

Qualifications

• Experience in drug discovery programs and decision-making in hit-to-lead, lead-op, or nomination.
• Strong background in medicinal chemistry, SAR/SPR, and lead optimization design.
• Expertise in ADME/DMPK, PK/PD interpretation, and exposure–response reasoning.
• Proficiency in computational chemistry, engineering, biochemistry, and ML.
• Ability to own customer relationships and partnerships with biotech and pharma.

Responsibilities

• Build and ship agentic tools and data systems to predict human drug outcomes.
• Own customer deliverables end-to-end: data generation, QC/QA, analysis, workflows, data presentation, and sponsor collaboration.
• Collaborate with sponsors, pharma researchers, AI labs, and internal teams to deploy agentic systems into discovery workflows.
• Embed customer goals with chemistry, biology, ML, engineering and lab teams; feed back customer needs into data generation and models.
• Expand and productionize insights from workflows; reduce analysis cycle time for subsequent customers.
• Perform independent analyses of data to improve quality and develop scalable analytical frameworks.
• Enable pharma drug hunters to define the future of drug discovery using agents, data, and experimental platform.

Skills

Python

RDKit

NumPy

Pandas

SQL

Education

Advanced degree in chemistry/cheminformatics/toxicology/computational chemistry

Tools

RDKit

Job description

Axiom is seeking exceptional drug discovery scientists with strong computational and mathematical instincts to help build our ecosystem. You will work directly with scientists at top pharma/biotech, researchers from leading AI labs, and Axiom’s multidisciplinary team to build experimental datasets, agentic systems, and product capabilities needed to predict human drug outcomes.

They will deploy these agents into real discovery workflows to inform go/no-go decisions on high-value programs.