Senior Manager, Technical Clinical Data Management

Deciphera Pharmaceuticals Inc.; Waltham (MA); On-site; USD 164,000 - 200,000; Full time

Benefits offered by this job

Competitive salary & annual bonus

Comprehensive benefits package

Generous parental leave

Professional growth opportunities

Job summary

Deciphera Pharmaceuticals Inc. in the United States seeks an experienced Senior Manager, Technical Clinical Data Management to lead end-to-end data management for assigned trials.

The role combines strategic CDM leadership with hands-on technical expertise to improve data quality, accelerate issue resolution, and support timely study delivery. You will oversee study timelines, manage CRO relationships, and partner with IT to streamline data transfers while applying data intelligence to monitor

Qualifications

• Bachelor's or Master's degree in Clinical Data Management.
• Knowledge of FDA CFR and ICH/GCP.
• Familiarity with CDISC and CDASH standards.
• Experience with data visualization tools to build study-status dashboards.
• Experience creating tools for clinical data workflows, including review, automation and visualization with validation and oversight.
• Familiarity with AI (e.g. Copilot, Claude).
• Effective communication, organizational, and project management skills.

Responsibilities

• Lead clinical data management and technical operations for assigned trials.
• Represent Data Management on the Clinical Study Team and manage CRO communications.
• Oversee Data Management Plan deliverables to meet quality and timelines.
• Strengthen vendor oversight and data transfer efficiency across systems.
• Collaborate with cross-functional teams on data deliverables.
• Improve CDM processes and cross-functional collaboration.
• Lead CDM inspection activities and manage findings to resolution.
• Ensure CDM documentation is filed in the TMF.

Skills

FDA CFR ICH GCP knowledge

CDISC/CDASH standards

Data visualization dashboards

Clinical data workflows tools

AI familiarity (Copilot, Claude)

Communication & organization

Education

Bachelor's or Master's degree in Clinical Data Management

Tools

Medidata RAVE

SAS

J-Review

Job description

Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together. Learn more about Deciphera, a member of Ono Pharmaceutical Co., Ltd., by visiting our website: https://deciphera.com

We are seeking an experienced Senior Manager, Technical Clinical Data Management to take full accountability for end-to-end data management lifecycle activities across assigned clinical trials. In this dual-function role, the individual will serve as the primary Data Management Study Lead, managing timelines, cross-functional communication, risks, and deliverables while also applying hands-on technical expertise. Candidate will combine strong clinical data management leadership with the technical ability to design efficient, scalable solutions that improve data quality, accelerate issue resolution, and support timely study delivery.

Key Responsibilities:

• Clinical Data Management Leadership & Technical Operations
• Leadership & Study Oversight
  • Represent Data Management on the Clinical Study Team, lead study communications, and manage expectations with the Data Management CRO
  • Oversee all activities defined in the Data Management Plan (DMP) and ensure study deliverables meet quality and timeline expectations
• Technical Operations
  • Advance vendor oversight by applying data intelligence to identify trends, strengthen performance monitoring, and improve operational efficiency
  • Partner with IT to streamline external data transfers and integrate data across systems for cross-functional use
• Vendor & Stakeholder Management
  • Oversee outsourced CDM vendors and ensure performance aligns with Deciphera standards
  • Review vendor invoices as applicable
  • Collaborate with cross functional team on data deliverables
• Leadership, Process & Continuous Improvement
  • Enhance CDM processes and strengthen cross functional collaboration
  • Support department initiatives as needed
• Inspection Readiness, Quality & Metrics
  • Lead CDM inspection activities and manage findings to resolution
  • Ensure CDM documentation is complete and filed in the TMF
• Other duties and responsibilities as assigned

Qualifications:

• Bachelor's or master's degree with 8+ years of experience in Clinical Data Management
• Knowledge of FDA/CFR and ICH/GCP
• Familiarity of CDISC and CDASH standards
• Experience with data visualization tools to build study-status and data quality dashboards
• Experience creating and applying tools to clinical data workflows, including data review, automation, and visualization with appropriate validation and human oversight
• Familiarity with AI (e.g. Copilot, Claude)
• Effective communication, organizational, and project management skills

Preferred Capabilities:

• Experience building in Medidata RAVE
• Hands on experience using SAS for data extraction and validation
• Experience with J-Review

Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $164,000 - $200,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.

Deciphera believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable)

Benefits:

• Competitive salary and annual bonus.
• Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
• Generous parental leave and family planning benefits.
• Outstanding culture and opportunities for personal and professional growth.

EQUAL EMPLOYMENT OPPORTUNITY INFORMATION Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.