Senior Manager, Quantitative Systems Pharmacology

Gilead Sciences, Inc.; Foster City (CA); On-site; USD 169,000 - 220,000; Full time

Job summary

Join an innovative firm dedicated to creating a healthier world through groundbreaking therapies. As a Senior Manager in Quantitative Systems Pharmacology, you will develop and apply mechanistic models that inform drug development processes. Collaborate with cross-functional teams to optimize drug candidates and identify biomarkers, while mentoring junior scientists. This role offers a unique opportunity to make a significant impact in the fight against serious health challenges. If you're passionate about scientific innovation and thrive in a collaborative environment, this is the perfect opportunity for you.

Benefits

Discretionary annual bonus

Stock-based long-term incentives

Paid time off

Medical, dental, and vision insurance

Life insurance plans

Qualifications

• 3+ years of relevant experience in QSP modeling.
• Proficiency in mathematical and computational skills for modeling work.

Responsibilities

• Develop QSP models for disease areas using in-house and published data.
• Communicate with cross-functional teams to update modeling strategies.

Skills

Mathematics and Computational Skills

QSP Modeling

Programming (Python, R, C++, Julia, MATLAB)

Statistical Analysis

Optimization Techniques

Basic Molecular Biology

Education

PhD or PharmD in relevant field

Education in Computational/Systems Biology

Tools

MATLAB SimBiology

Bioinformatics Tools

Job description

Senior Manager, Quantitative Systems Pharmacology

Senior Manager, Quantitative Systems Pharmacology

United States - California - Foster City Clinical Development & Clinical Operations Regular

Job Description

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

As a Quantitative Systems Pharmacologist, your main role will be in scoping, developing and applying mechanistic disease progression and systems pharmacology models at Gilead. In this role, you will have opportunities to inform multiple aspects of the drug development process including optimizing drug candidates through mechanistic simulation, dose/target optimization, identifying biomarkers for clinical programs, and recommending doses, regimens and subpopulations for inclusion into clinical trial design. Further areas of focus include reverse translation of clinical findings and development of platform models to support combinations and inform portfolio development strategy.

Responsibilities

• Develop QSP models for one or more disease areas incorporating available in-house and published data
• Regularly communicate with cross-functional teams to develop and periodically update modeling strategy to ensure timely and impactful execution of modeling goals
• Present model findings to clinical teams and incorporate feedback as needed
• Provide expert guidance across teams as needed
• Contribute to regulatory documents using the appropriate level of documentation and reproducibility
• Maintain accurate records including data, assumptions, parameter values, model changes, etc. while developing models
• Proactively identify opportunities for applying or adapting QSP models to support portfolio and project needs
• Develop and maintain reusable software tools as needed to support and streamline QSP efforts
• Author manuscripts describing model development and findings as needed
• Present modeling work externally at conferences and working groups
• Mentor junior scientists on areas related to QSP, if needed

Required Experience and Skills:

• Proficiency in mathematical and computational skills needed for QSP modeling work, including but not limited to ordinary differential equations, linear algebra, statistics, optimization, and parameter inference
• Relevant education in computational/systems biology, physics, engineering, or computer science
• Proficiency in relevant software and programming languages which may include python, R, C++, Julia, or MATLAB and MATLAB SimBiology (preferred)
• Basic understanding of molecular and cellular biology including for example concepts from immunology, oncology, virology, cellular signaling, etc.
• Basic understanding of concepts of drug development
• 3+ years of relevant experience and a PhD or PharmD degree

Preferred skills:

• Experience with QSP software and Bioinformatics tools for informing QSP models
• Familiarity with other modeling techniques: ABMs, PDEs, SDEs, SSA, graph theoretical methods, information theoretical methods, Boolean networks, etc.
• Familiarity with methodologies for Bayesian parameter inference
• Expert knowledge in one or more relevant disease areas (oncology, inflammation, virology)
• Machine learning and AI expertise (LLMs, classical methods for regression or classification)
• Experience with pharmacokinetic/pharmacodynamic modeling in small molecules and biologics or other pharmacometric modeling experience
• Familiarity with drug development and clinical pharmacology in a pharmaceutical company setting

Job Description

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

As a Quantitative Systems Pharmacologist, your main role will be in scoping, developing and applying mechanistic disease progression and systems pharmacology models at Gilead. In this role, you will have opportunities to inform multiple aspects of the drug development process including optimizing drug candidates through mechanistic simulation, dose/target optimization, identifying biomarkers for clinical programs, and recommending doses, regimens and subpopulations for inclusion into clinical trial design. Further areas of focus include reverse translation of clinical findings and development of platform models to support combinations and inform portfolio development strategy.

Responsibilities

• Develop QSP models for one or more disease areas incorporating available in-house and published data
• Regularly communicate with cross-functional teams to develop and periodically update modeling strategy to ensure timely and impactful execution of modeling goals
• Present model findings to clinical teams and incorporate feedback as needed
• Provide expert guidance across teams as needed
• Contribute to regulatory documents using the appropriate level of documentation and reproducibility
• Maintain accurate records including data, assumptions, parameter values, model changes, etc. while developing models
• Proactively identify opportunities for applying or adapting QSP models to support portfolio and project needs
• Develop and maintain reusable software tools as needed to support and streamline QSP efforts
• Author manuscripts describing model development and findings as needed
• Present modeling work externally at conferences and working groups
• Mentor junior scientists on areas related to QSP, if needed

Required Experience and Skills:

• Proficiency in mathematical and computational skills needed for QSP modeling work, including but not limited to ordinary differential equations, linear algebra, statistics, optimization, and parameter inference
• Relevant education in computational/systems biology, physics, engineering, or computer science
• Proficiency in relevant software and programming languages which may include python, R, C++, Julia, or MATLAB and MATLAB SimBiology (preferred)
• Basic understanding of molecular and cellular biology including for example concepts from immunology, oncology, virology, cellular signaling, etc.
• Basic understanding of concepts of drug development
• 3+ years of relevant experience and a PhD or PharmD degree

Preferred skills:

• Experience with QSP software and Bioinformatics tools for informing QSP models
• Familiarity with other modeling techniques: ABMs, PDEs, SDEs, SSA, graph theoretical methods, information theoretical methods, Boolean networks, etc.
• Familiarity with methodologies for Bayesian parameter inference
• Expert knowledge in one or more relevant disease areas (oncology, inflammation, virology)
• Machine learning and AI expertise (LLMs, classical methods for regression or classification)
• Application development experience (e.g. in MATLAB AppDesigner)
• Experience with pharmacokinetic/pharmacodynamic modeling in small molecules and biologics or other pharmacometric modeling experience
• Familiarity with drug development and clinical pharmacology in a pharmaceutical company setting

The salary range for this position is: $169,320.00 - $219,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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Job Requisition ID R0044956

Full Time/Part Time Full-Time

Job Level Manager

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