Senior Manager, Process Engineering

Vertex Pharmaceuticals LLC; Boston (MA); Hybrid; USD 140,000 - 210,000; Full time

Benefits offered by this job

Annual bonus

Annual equity awards

Job summary

Vertex Pharmaceuticals LLC in Boston is seeking a Senior Manager, Process Engineering to provide technical and operational leadership across complex manufacturing activities. This role partners with CPI and DSDP, supporting Leiden Center needs and driving process development with compliance at the forefront.

The position requires a strong background in GMP/CMC, technology transfer, and validation, with visibility across cross-functional teams.

Qualifications

• Bachelor's degree required in a relevant field.
• Advanced knowledge of GMPs and CMC concepts.
• Experience leading pharmaceutical process engineering projects.
• Understanding of technology transfer and validation processes.

Responsibilities

• Provide technical and strategic leadership across complex manufacturing activities.
• Represent Process Engineering in cross-functional teams and drive development decisions.
• Develop master plans for technology transfers and process validations.
• Lead and develop staff, with financial and HR accountability.
• Ensure compliance with quality, regulatory, and business requirements.

Skills

GMP knowledge

CMC regs

Project management

Data analysis

QbD & DOE

Education

Bachelor's degree in relevant field

Master's degree

PhD

Job description

## Senior Manager, Process EngineeringApply: Boston, MA: Full time: Posted Today: REQ-30148**Job Description**### **General Summary:**The Senior Manager, Process Engineering reports to the Senior Director of Manufacturing. The role is an emerging leadership position within the organization, providing technical, strategic, and operational leadership across complex manufacturing activities. This individual represents the Process Engineering function in cross-functional settings and helping to advance late and early - stage process and product development while reducing commercialization risk. The Senior Manager builds productive stakeholder relationships, translates departmental priorities into actionable plans, and leads a team of employees in delivering high-quality, compliant, and scalable outcomes. The position also supports the technical and compliance needs of CPI and DSDP, partnering closely with relevant stakeholders to ensure manufacturing activities are aligned with applicable quality, regulatory, and business requirements. This position reports to the Senior Director of Manufacturing and supports operations at the Leiden Center. The Senior Manager serves as a key Process Engineering partner for CPI and DSDP, ensuring their technical and compliance needs are addressed through effective planning, issue resolution, documentation, and cross-functional collaboration.### **Key Duties and Responsibilities:*** Serve as a technical resource in one or more process engineering areas, adapting departmental plans and priorities to meet short-term operational objectives.* Contribute to the development and implementation of departmental tools, standards, and best practices that support consistent execution and continuous improvement.* Represent Process Engineering on cross-functional CMC teams, influencing late and early -stage process and product development decisions.* Develop and execute manufacturing strategies for technology transfers and process validations, including strategic master plans, protocols, and technical reports.* Establish and maintain effective working relationships with key suppliers of materials, technologies, and manufacturing resources.* Evaluate process performance through statistical process control methods; identify, prioritize, and lead continuous improvement initiatives across the product lifecycle.* Resolve complex manufacturing issues by applying new perspectives to existing solutions and support timely, scientifically sound resolution of quality investigations.* Support CPI and DSDP technical and compliance needs at the Leiden Center, ensuring process engineering activities, documentation, and decisions meet applicable quality and regulatory expectations.* Lead and develop assigned staff; as a people manager, assume appropriate financial accountability and human resource responsibilities.### ### **Knowledge and Skills:*** Advanced knowledge of GMPs and associated CMC regulatory considerations in a pharmaceutical environment.* Demonstrated experience managing projects within the pharmaceutical industry.* Strong understanding and practical application of technology transfer and validation processes.* Strong communication, collaboration, and team-building skills, with the ability to connect effectively at all organizational levels.* Ability to manage multiple high-priority projects concurrently and influence stakeholders in a strong-matrix environment.* Mastery of complex data analysis, mathematical modeling,* Working knowledge of Quality by Design (QbD) principles and design of experiments methodology and implementation.### ### **Education and Experience:*** Bachelor's degree in relevant field* PhD and 2+ years, or Master's and 5+ years, or Bachelor's and 8+ years. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.**Pay Range:**$140,000 - $210,000**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**On-Site Designated**Flex Eligibility Status:**In this **On-Site** designated role, you will work **five days per week on-site** with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.