Senior Manager Portfolio Management

Regeneron Pharmaceuticals; Tarrytown (GA); On-site; USD 134,000 - 219,000; Full time

Job summary

Regeneron Pharmaceuticals is seeking a Senior Manager, Portfolio Management to own key portfolio management processes and drive portfolio planning and review activities across Global Development. You will translate complex portfolio information into actionable insights, partner with Clinical Development, Finance, Operations, and other functions, and enhance portfolio visibility, planning, and execution.

The role requires 8+ years in portfolio/program management or related fields, with strong

Qualifications

• Minimum Master’s degree in a scientific, business, or related discipline.
• 8+ years of experience in portfolio/program management, strategy consulting, business operations, strategic planning, pharmaceutical development, or related functions.
• Demonstrated experience leading cross-functional initiatives.
• Strong analytical, problem-solving, and critical-thinking skills.
• Advanced PowerPoint and Excel capabilities.
• Exceptional written and verbal communication skills with the ability to tailor messages to executive audiences.
• Proven ability to manage multiple priorities in a highly matrixed environment.

Responsibilities

• Own the planning and execution of assigned portfolio reviews and portfolio planning activities, including timelines, deliverables, stakeholder engagement, content integration, and meeting readiness.
• Lead cross-functional preparation efforts to ensure portfolio discussions are supported by accurate, timely, and decision-relevant information.
• Partner with stakeholders across Clinical Development Units, Development Program Management, Resource Management, Finance, and other functions to consolidate portfolio inputs and ensure alignment on key messages and discussion topics.
• Support the Director of Portfolio Management in enterprise-level portfolio reviews and other strategic portfolio initiatives.
• Develop portfolio analyses that identify execution risks, portfolio constraints, milestone impacts, prioritization challenges, and opportunities requiring management attention.
• Assess portfolio trends and emerging issues to support discussions regarding resource allocation, portfolio trade-offs, and execution planning.
• Develop clear recommendations, discussion materials, and supporting analyses for leadership review.
• Support the Director of Portfolio Management in evaluating broader portfolio scenarios, prioritization discussions, and portfolio optimization opportunities.
• Own assigned portfolio management processes and ensure consistent execution, defined deliverables, and ongoing process improvement.
• Establish and maintain standardized templates, workflows, and operating procedures that improve efficiency, transparency, and consistency across portfolio activities.
• Monitor process performance and recommend enhancements to improve the quality and effectiveness of portfolio management activities.
• Support the Director of Portfolio Management in evolving portfolio management capabilities and operating models.
• Develop executive presentations, portfolio summaries, briefing materials, and leadership communications that synthesize complex portfolio information into concise and actionable insights.
• Own recurring portfolio reporting activities, including status updates, portfolio summaries, milestone tracking, and leadership communications.
• Track and communicate key portfolio developments, risks, actions, and outcomes arising from portfolio review discussions and planning activities.

Skills

Analytical thinking

Executive communication

Project management

Advanced PowerPoint and Excel

Education

Master’s degree in a scientific, business, or related discipline

Tools

PowerPoint

Excel

Job description

Build our future together:

The Senior Manager, Portfolio Management is responsible for owning key portfolio management processes and supporting the execution of portfolio planning and review activities across Global Development. This role serves as a strategic partner to the Director of Portfolio Management, translating complex portfolio information into actionable insights, facilitating cross-functional alignment, and driving the execution of portfolio operating processes that support informed decision-making.

The successful candidate will independently lead assigned portfolio management workstreams, develop executive-level analyses and communications, and partner with stakeholders across Clinical Development, Research, Finance, Operations, and other functions to improve portfolio visibility, planning, and execution. Portfolio review frameworks, planning activities, portfolio reporting, prioritization discussions, and portfolio operating processes are recurring responsibilities within the team’s work.

When & where:

• Primary Location: Tarrytown, NY
• Additional Locations: Warren, NJ or Cambridge, MA

Discover your role:

Portfolio Review & Planning Execution

• Own the planning and execution of assigned portfolio reviews and portfolio planning activities, including timelines, deliverables, stakeholder engagement, content integration, and meeting readiness.
• Lead cross-functional preparation efforts to ensure portfolio discussions are supported by accurate, timely, and decision-relevant information.
• Partner with stakeholders across Clinical Development Units, Development Program Management, Resource Management, Finance, and other functions to consolidate portfolio inputs and ensure alignment on key messages and discussion topics.
• Support the Director of Portfolio Management in enterprise-level portfolio reviews and other strategic portfolio initiatives.

Portfolio Assessment & Decision Support

• Develop portfolio analyses that identify execution risks, portfolio constraints, milestone impacts, prioritization challenges, and opportunities requiring management attention.
• Assess portfolio trends and emerging issues to support discussions regarding resource allocation, portfolio trade-offs, and execution planning.
• Develop clear recommendations, discussion materials, and supporting analyses for leadership review.
• Support the Director of Portfolio Management in evaluating broader portfolio scenarios, prioritization discussions, and portfolio optimization opportunities.

Portfolio Operating Process Ownership

• Own assigned portfolio management processes and ensure consistent execution, defined deliverables, and ongoing process improvement.
• Establish and maintain standardized templates, workflows, and operating procedures that improve efficiency, transparency, and consistency across portfolio activities.
• Monitor process performance and recommend enhancements to improve the quality and effectiveness of portfolio management activities.
• Support the Director of Portfolio Management in evolving portfolio management capabilities and operating models.

Executive Communications & Portfolio Reporting

• Develop executive presentations, portfolio summaries, briefing materials, and leadership communications that synthesize complex portfolio information into concise and actionable insights.
• Own recurring portfolio reporting activities, including status updates, portfolio summaries, milestone tracking, and leadership communications.
• Track and communicate key portfolio developments, risks, actions, and outcomes arising from portfolio review discussions and planning activities.

Cross-Functional Portfolio Partnership

• Serve as the primary portfolio management partner for assigned functions, portfolio segments, or review processes.
• Lead cross-functional working sessions to align stakeholders on portfolio assumptions, risks, dependencies, and recommendations.
• Build productive relationships across stakeholder groups and facilitate resolution of issues affecting portfolio planning and execution.
• Support the Director of Portfolio Management in engaging senior leaders and preparing for portfolio-related discussions and decision forums.

This role requires:

• Minimum Master’s degree in a scientific, business, or related discipline.
• 8+ years of experience in portfolio/program management, strategy consulting, business operations, strategic planning, pharmaceutical development, or related functions.
• Demonstrated experience leading cross-functional initiatives.
• Strong analytical, problem-solving, and critical-thinking skills.
• Advanced PowerPoint and Excel capabilities.
• Exceptional written and verbal communication skills with the ability to tailor messages to executive audiences.
• Proven ability to manage multiple priorities in a highly matrixed environment.

Preferred

• Experience supporting pharmaceutical R&D or development portfolios.
• Experience developing executive-level presentations and strategic communications.
• Familiarity with portfolio planning, prioritization, resource management, and portfolio review processes.
• Experience working with senior leadership teams and enterprise-level initiatives.

What Success Looks Like

• Successfully owns assigned therapeutic area portfolio reviews and planning workstreams with minimal oversight.
• Recognized as a trusted portfolio management partner by stakeholders across functions.
• Delivers actionable portfolio analyses that improve the quality of portfolio discussions and decisions.
• Produces high-quality executive communications that drive alignment and informed decision-making.
• Contributes meaningfully to the continued evolution of the portfolio management function and operating model.

Does this sound like you? We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$134,400.00 - $219,200.00