Senior Manager, Genomics Lab Operations & Variant Science

Regeneron Pharmaceuticals, Inc.; Tarrytown (GA); On-site; USD 137,000 - 224,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks a Senior Manager for Clinical Laboratory Services to oversee the Clinical Genomics Laboratory in Tarrytown, NY.

This role combines hands-on laboratory oversight with collaboration across stakeholders to ensure compliant, high-quality genetic testing. The successful candidate will lead NextGen sequencing operations, drive process improvements, and mentor staff while maintaining regulatory standards (CLIA, NY CLEP, CAP).

Qualifications

• Doctoral degree or equivalent in a chemical, physical, biological, or clinical laboratory science (or medicine).
• 5+ years of experience in a next generation sequencing clinical laboratory.
• 2+ years of laboratory training/experience in the specialty.
• Project management certification is a plus.

Responsibilities

• Direct and oversee daily NextGen Sequencing clinical laboratory operations, including workflow, sample processing, testing, and post-analytical processes.
• Provide operational leadership and technical guidance, define scope of work, drive execution, and deliver results in a fast-paced environment.
• Ensure regulatory compliance with NYS DOH, CLIA, CAP, and other accrediting bodies; monitor QC procedures for accurate results.
• Participate in design and performance of test validation: method validation, performance evaluation, verification of assays.
• Serve as Variant Scientist, supporting genetic variant curation and ACMG classification scoring.
• Develop and maintain required documentation (SOPs, policies, protocols).
• Promote continuous improvement and risk mitigation across processes.
• Analyze and report quality indicators, track trends, and communicate risks.
• Lead laboratory staff including hiring, training, performance management, and day-to-day supervision.

Skills

Leadership

Regulatory compliance

Quality assurance

Project management

Education

PhD in chemical/physical/biological/clinical laboratory science (or medicine)

Job description

Regeneron Pharmaceuticals, Inc. seeks a Senior Manager for Clinical Laboratory Services to oversee the Clinical Genomics Laboratory in Tarrytown, NY.

This role combines hands-on laboratory oversight with collaboration across stakeholders to ensure compliant, high-quality genetic testing. The successful candidate will lead NextGen sequencing operations, drive process improvements, and mentor staff while maintaining regulatory standards (CLIA, NY CLEP, CAP).