Clinical Bioinformatician — NGS Pipeline Lead

Regeneron Pharmaceuticals, Inc.; Tarrytown (GA); Hybrid; USD 96,000 - 156,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. in Tarrytown, NY seeks an experienced Clinical Bioinformatician to lead optimization, validation, and production support of NGS pipelines in a regulated CLIA environment. Hybrid work arrangement with 4 days on site weekly.

The role demands strong collaboration across scientific, operational, and leadership teams, with a focus on regulatory compliance and data integrity. 2–4 years in clinical genomics and expertise in Linux, Python or R preferred.

Qualifications

• Master's or bachelor with substantial CLIA-regulated clinical genomics experience.
• 2–4 years in a clinical molecular diagnostics or genomics lab with NGS validation.
• Proven experience validating NGS pipelines in CLIA setting.
• Experience with short-read sequencing data QC and troubleshooting.
• Experience validating vendor secondary analysis platforms in clinical setting.
• Familiar with FASTQ, BAM/CRAM, VCF formats and QC tools.
• Proficiency in Linux/Unix and scripting in Python or R.

Responsibilities

• Lead or co-lead analytical validation and revalidation of NGS pipelines.
• Benchmark and select tools for alignment, variant calling, and QC.
• Oversee daily execution of validated clinical pipelines and monitor QC KPIs.
• Support change management, impact assessments, and version control.
• Contribute to pipeline design, development, and containerization.
• Ensure data management and regulatory compliance; audit-ready records.
• Monitor cloud costs and provide usage data for budgeting.

Skills

NGS data analysis

Regulatory compliance

Cross-functional collaboration

Independent work

Education

Master's in Bioinformatics or related field

Bachelor's with CLIA experience

Tools

Linux/Unix

Python

R

Job description

Regeneron Pharmaceuticals, Inc. in Tarrytown, NY seeks an experienced Clinical Bioinformatician to lead optimization, validation, and production support of NGS pipelines in a regulated CLIA environment. Hybrid work arrangement with 4 days on site weekly.

The role demands strong collaboration across scientific, operational, and leadership teams, with a focus on regulatory compliance and data integrity. 2–4 years in clinical genomics and expertise in Linux, Python or R preferred.