Senior Manager, Drug Substance

Scorpion Therapeutics; Boston (MA); Hybrid; USD 150,000 - 200,000; Full time

Job summary

Scorpion Therapeutics seeks a Senior Manager, Drug Substance to oversee development and manufacturing of small molecule APIs for clinical stages, ensuring scalable processes, safety, and regulatory compliance.

You will lead CDMO teams through scale-up for GLP/GMP studies, coordinate technology transfers, review batch records, and tackle process chemistry challenges while developing technical documentation. Hybrid Boston travel may be required.

Qualifications

• B.S./M.S. in Chemistry required.
• 6+ years in small molecule process chemistry.
• Experience with cGMP and technology transfers.

Responsibilities

• Manage CDMO teams in process scale-up for GLP and GMP studies.
• Facilitate technology transfers.
• Review batch records.
• Address process chemistry challenges.
• Develop technical documentation.

Skills

Project management

Independent work

Communication

Education

B.S./M.S. in Chemistry

Job description

Role

Senior Manager, Drug Substance overseeing development and manufacturing of small molecule APIs for clinical stages, ensuring process scalability, safety, and regulatory compliance.

Responsibilities

• manage CDMO teams in process scale-up for GLP and GMP studies
• facilitate technology transfers
• review batch records
• address process chemistry challenges
• develop technical documentation

Qualifications

• B.S./M.S. in Chemistry
• 6+ years in small molecule process chemistry
• extensive experience in process development
• tech transfer
• cGMP requirements

Preferred

• strong project management skills
• ability to work independently in a fast-paced environment
• excellent communication

High-Value

• focus on small molecule drug development, process scale-up, and transfer
• experience with early to late-stage GMP clinical manufacturing
• collaboration with CDMOs across phases

Work Setup

Hybrid Boston, with some travel expected.