Senior Manager, Commercial Accounting and Operations

Denali Therapeutics Inc; South San Francisco (CA); On-site; USD 151,000 - 196,000; Full time

Benefits offered by this job

401k

Healthcare coverage

ESPP

Broad range of other benefits

Job summary

Denali Therapeutics Inc. is seeking a senior finance professional to lead day-to-day revenue cycle operations for its first commercial product, covering order management, revenue recognition, GTN, and receivables within SAP environments.

Reporting to the Director, Commercial Finance, the role emphasizes scalable processes, SOX controls, and collaboration with Commercial, Market Access and Supply Chain to support global expansion and accurate financial reporting.

Qualifications

• Bachelor's or Master's in Accounting, Finance, or related field.
• CPA strongly preferred (active or inactive).
• 10+ years of progressive accounting and finance experience including ASC 606.
• Experience leading order-to-cash operations and revenue accounting.
• Strong US GAAP, SOX compliance, and public company reporting.
• Experience with SAP, FloQast, Workiva.
• Pharma/biotech/life sciences industry experience preferred.

Responsibilities

• Oversee daily order management, revenue recognition and GTN processes end-to-end.
• Manage AR operations, collections, cash application and credit.
• Review commercial agreements for revenue implications and maintain SOX controls.

Skills

O2C ownership

US GAAP knowledge

SOX compliance

Cross-functional collaboration

Advanced Excel

AI tools integration

Education

Bachelor's or Master's in Accounting/Finance

CPA (preferred)

Tools

SAP

FloQast

Workiva

Job description

Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood‑brain barrier (BBB) using its proprietary TransportVehicle™ platform. With the first FDA‑approved biologic specifically designed to cross the BBB, a clinically validated delivery platform and a growing portfolio of therapeutic candidates across all stages of development, we are advancing toward our goal of delivering effective medicines to transform the lives of people living with neurodegenerative diseases, lysosomal storage disorders and other serious diseases. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Reporting to the Director, Commercial Finance, this role owns day‑to‑day execution across the commercial revenue cycle for our first commercial product, including order management, order‑to‑cash, accounts receivable and credit management, pricing operations, revenue recognition and gross‑to‑net reserves, and commercial‑cycle close and controls. As the commercial footprint expands across products and geographies, this role is expected to build scalable, well‑controlled processes rather than simply operate existing ones. This is a self‑contributor role which expects to expand in the future as Denali scale and grow across the pipeline of drug candidates.

Key Accountabilities/Core Job Responsibilities

• Order Management, Revenue Recognition and Gross‑to‑Net (“GTN”) Oversee daily order management, including order review and release, credit and compliance holds, pricing conditions, delivery confirmation, and billing execution in SAP. Serve as the finance process owner for the end‑to‑end order‑to‑cash process, from customer master and contract setup through invoicing and cash application, all the way to closing the books and finalizing accounting reconciliations. Manage the operational and financial interface with the third‑party logistics provider, specialty distributors, and international distribution partners, including order flow, delivery reporting, fee and chargeback submissions, and monthly reconciliations. Lead the preparation, analysis, and review of GTN and the related roll‑forward. Prepare revenue and GTN inputs for external reporting, including the product revenue footnote, GTN roll‑forward tables, and supporting tie‑outs for 10‑Q and 10‑K filings.
• Treasury Operations, Accounts Receivable and Credit Management Manage accounts receivable operations, including aging review, collections cadence, cash application, deduction and dispute resolution. Develop, implement and maintain the policy around allowance for credit losses. Assist with treasury operations, including daily cash positioning, bank account administration and access, and preparation of short‑term cash forecasts supporting liquidity management.
• Technical Accounting and Contracts Review Review commercial agreements for financial terms, revenue recognition implications, and downstream system and process impacts. Assist with preparation of technical accounting memos on revenue and commercial arrangements, including ASC 606 analyses, new contract structures, and implementation of new accounting standards. Maintain the revenue recognition accounting policy and related position papers and support their review with the Controller organization and external auditors. Serve as process owner for commercial‑cycle SOX controls.

Qualifications/Skills

• Bachelor's or Master degree in Accounting, Finance, or a related field is required.
• CPA strongly preferred (active or inactive); Big Four public accounting experience strongly preferred.
• Typically requires a minimum of 10 years of progressive accounting and finance experience, including commercial and revenue accounting under ASC 606.
• Demonstrated ownership of order‑to‑cash operations, including order management, accounts receivable, collections, and customer credit, at a subject‑matter‑expert level.
• Strong working knowledge of U.S. GAAP, SOX compliance, and public company reporting requirements.
• Demonstrated ability to partner cross‑functionally with Commercial, Market Access, Supply Chain, IT, Legal, and Tax, and to communicate financial concepts to non‑finance stakeholders.
• Ability to operate effectively in a fast‑paced, early commercial environment where processes are still being built.
• Preferred Experience International commercial experience.
• Advanced Excel skills and comfort working with large transactional data sets and reconciliations.
• Demonstrated commitment to actively leveraging AI tools and proactively identifying opportunities to integrate AI into processes and workflows.
• Familiarity with U.S. government pricing programs, including Medicaid, 340B, and Medicare Part D.
• Experience with SAP, FloQast, Workiva.
• Experience in a pharmaceutical, biotechnology, or life sciences company.

Salary Range: $151,000.00 to $196,000.00.

Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Learn more at https://www.denalitherapeutics.com/careers. This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Benefits

• 401k
• healthcare coverage
• ESPP
• broad range of other benefits

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

“Life at Denali” is a living reflection of our values: trust, unity, grit and growth. These are not just words we share—they shape how we show up, collaborate and push boundaries together.

From the lab to the community, across functions and milestones, our culture thrives on shared purpose and relentless pursuit.