Associate Director, Commercial Finance

Denali Therapeutics; South San Francisco (CA); Hybrid; USD 159,000 - 207,000; Full time

Benefits offered by this job

401k

Healthcare coverage

ESPP

Job summary

Denali-Therapeutics in California is seeking a senior FP&A leader to own product P&L forecasting, GTN analyses, and long-range planning within CMPA finance. You will partner with Commercial, Supply Chain, and Accounting to translate revenue and cost dynamics into forecasts and board-ready insights.

You will lead budgeting, quarterly closes, and incentive-forecasting, shaping how the commercial portfolio allocates resources while ensuring GAAP-aligned revenue accounting and SOX control readiness.

Qualifications

• Bachelor’s degree in Finance, Accounting, Business Administration or related field.
• MBA or relevant advanced degree preferred.
• 12 years of relevant finance experience with focus on commercial finance/FP&A and GTN forecasting in biotech/pharma.

Responsibilities

• Own product P&L forecasting and analysis with key stakeholders.
• Maintain GTN forecasting model and related analytics (rebates, chargebacks, discounts, returns, programs).
• Lead annual budgets, forecasts and long-range planning for CMPA teams.
• Collaborate on monthly/quarterly close, accruals, and revenue/GTN reconciliations.
• Partner on incentive compensation forecasting and distributor economics.
• Support commercial contracts and profitability analyses.
• Coordinate with Supply Chain on S&OP and risks/opportunities.
• Drive forecasting improvements, controls, and audit readiness.

Skills

Financial modeling

FP&A

Strategic partnership

Cross-functional collaboration

Analytical thinking

Communication

Education

Bachelor’s degree in Finance/Accounting/Business Administration

MBA or related advanced degree

Tools

MS Excel

SAP

ERP systems

Job description

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.This role will bring financial rigor and strategic insight to Denali's commercial and lifecycle planning within the Commercial, Medical Affairs, and Patient Advocacy (CMPA) organization. Partnering closely with Commercial, Supply Chain, and Accounting, the individual in this role translates revenue, cost, and gross-to-net dynamics into forecasts and analyses that inform Board-level and long-range planning decisions. By owning core forecasting models and surfacing actionable insights from sales, pricing, and GTN trends, this position directly shapes how Denali allocates resources and manages risk as its commercial portfolio grows. This position reports to the Executive Director, Head of CMPA Finance.Key Accountabilities/Core Job Responsibilities :Own product P&L forecasting and analysis, partnering with Commercial, Supply Chain, Accounting, and other key stakeholders to align revenue, cost, and other key P&L assumptions and support business reviews, Board meetings, and long-range planningOwn and maintain GTN forecasting model and related analytics, including rebates, chargebacks, discounts, returns, government programs, and channel utilization, in collaboration with Commercial Global Insights & Operations, Government Pricing, Channel Operations, Accounting, and other key stakeholders.Analyze sales, inventory, pricing and GTN trends, identify forecast variances and provide actionable insights to support commercial strategy and decision-making.Serve as a strategic finance partner to CMPA teams, leading annual budgets, forecasts, long-range planning, resource prioritization, and other FP&A analysesPartner with Accounting on monthly and quarterly close, including accruals, open commitments, revenue/GTN reconciliations and preliminary close analysis.Collaborate with Commercial and HR on incentive compensation forecasting and tracking of actual performance versus plan.Provide financial support for commercial contracts, customer agreements and distributor economics, including profitability and scenario analysis.Partner with Supply Chain on S&OP, aligning demand and supply assumptions with financial forecasts and highlighting key risks and opportunities.Lead special analyses and process improvements, including strengthening forecasting, reporting, controls, audit readiness and coordination of revenue/GTN-related audit requests.Qualifications/Skills :Bachelor’s degree in Finance, Accounting, Business Administration, or a related field. MBA or relevant advanced degree preferredTypically requires 12 years of relevant finance experience, with a significant focus on commercial finance/FP&A and GTN forecasting within biotech/pharmaceutical companiesCommercial launch and early post-launch experience is a plusDemonstrated experience as a strategic finance business partner in a fast-paced, dynamic environmentStrong analytical and financial modeling skills (product forecasts, P&L, NPV models, etc.)Strong knowledge of the pharmaceutical business including drug development and commercializationDemonstrated ability to lead cross-functional initiatives, influence without authority, and manage complex projectsStrategic thinker with the ability to operate in a capital efficient environment and align financial priorities with business objectivesSuperior communication and presentation skills, capable of conveying complex financial information to non-financial stakeholdersExperience in developing and implementing financial strategies that drive business growth and profitabilityWorking knowledge of GAAP revenue accounting principles; SOX experience a plusProficiency in Microsoft Office Suite and financial software and systems, such as SAPHybrid role that requires on-site SSF presence at least 3 days per week.Salary Range: $159,000.00 to $207,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careersThis compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.