Senior Manager, Biostatistics

Alexion Pharmaceuticals, Inc.; Boston (MA); On-site; USD 120,000 - 157,000; Full time

Benefits offered by this job

Retirement benefits

Paid time off

Health, dental, and vision coverage

Job summary

Alexion Pharmaceuticals, Inc. in Boston, MA seeks a Senior Manager, Biostatistics to lead independent statistical activities across clinical trial design, delivery and interpretation, and regulatory submissions.

This role coaches staff, develops creative statistical approaches, and collaborates across functions to improve study quality and efficiency. Requirements include MSc/PhD in statistics or math with a substantial statistical component, 1–2 years in pharma, SAS and R proficiency, and

Qualifications

• MSc/PhD in Statistics or Mathematics with a strong statistical component required.
• 1-2 years of experience in pharmaceutical industry.
• Competent statistical programmer (SAS and R).
• Knowledge of key technical and regulatory requirements.
• Experience in design, analysis and reporting of preclinical or clinical studies in multiple settings.
• Excellent communication and collaboration skills.

Responsibilities

• Provide statistical expertise for complex design and interpretation for preclinical or clinical programs and regulatory submissions.
• Analyze internal and external information, perform modelling to inform design decisions.
• Develop a Statistical Analysis Plan for complex studies.
• Coach less experienced statisticians in analyses, graphics, and study reports.
• Analyze, interpret, summarize and communicate results of complex studies.
• Contribute to regulatory submissions including overview documents and responses.
• Identify opportunities to apply modelling and simulation to improve design.
• Identify opportunities to improve methodology and deliver practical solutions.
• Contribute to development of best practices to improve quality and efficiency.
• Ensure quality of statistical work and pursue coaching or training as needed.

Skills

SAS

R programming

Statistical analysis

Communication skills

Collaboration

Education

MSc/PhD in Statistics or Mathematics containing a substantial statistical component

PhD in Statistics/Biostatistics preferred

Job description

This Is What You Will Do

The Senior Manager, Biostatistics has sufficient experience working as a statistician in the pharmaceutical industry to be working independently on activities relating to clinical trial design, delivery and interpretation, preclinical studies, regulatory submissions and/or commercialization. This individual is able to perform and communicate results of more technical analyses, and able to guide less experienced staff. They have the scope to develop creative statistical ideas and approaches, and to apply them in their work. Competent individual contributor with excellent cross-functional collaboration.

This Is What You Will Do

The Senior Manager, Biostatistics has sufficient experience working as a statistician in the pharmaceutical industry to be working independently on activities relating to clinical trial design, delivery and interpretation, preclinical studies, regulatory submissions and/or commercialization. This individual is able to perform and communicate results of more technical analyses, and able to guide less experienced staff. They have the scope to develop creative statistical ideas and approaches, and to apply them in their work. Competent individual contributor with excellent cross-functional collaboration.

You Will Be Responsible For

• Provide statistical expertise for complex design and interpretation for preclinical or clinical programmed, high level internal governance committees, regulatory submissions and/or commercialization
• Analyze internal and external information, perform modelling and simulation to inform design decisions and the development of decision criteria
• Develop a Statistical Analysis plan for complex studies and/or project deliveries
• Act as a coach/guide for less experienced statisticians in the production of analysis, supporting graphics and analysis tables for study reports, Global Medical Affairs studies or publications
• Able to analyze, interpret, summarize and communicate results of complex studies
• Contribute to the regulatory submissions including specification of overview documents and response to regulatory questions
• Identify opportunities for the application of modelling and simulation to improve study design
• Identify opportunities to improve the methodology and provide practical solutions for problems
• Identify and apply statistical methodology to improve the process and delivery activities
• Contribute to the development of best practice to improve quality, efficiency and effectiveness
• Accountable for the quality of their statistical work; provide discipline-specific understanding, insight and constructive challenge and take ownership of development needs, seek coaching or training opportunities

You Will Need To Have

• MSc/PhD in Statistics, Mathematics (containing a substantial statistical component), or recognized equivalent to stats MSc
• 1-2 years of experience in pharmaceutical industry
• Competent statistical programmer (SAS and R)
• Knowledge of key technical and regulatory requirements
• Experience of design, analysis and reporting of preclinical or clinical studies in more than one setting
• Communication skills
• Collaboration and team working skills
• Experience and knowledge of statistical methods and applications in study design, analysis and interpretation
• Flexible, well-organized, and possess the ability to work well under pressure.
• The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We Would Prefer For You To Have

• PhD in Statistics/Biostatistics is preferred.
• Collaboration required
• Ability to apply statistical expertise to problems, and problem solving and quality focus

Joining Alexion means embracing an opportunity where work isn’t ordinary. We are a beacon in the global Biopharmaceutical landscape. Our closeness to patients brings us closer to our work and each other. Combined with our brave, pioneering spirit – we are truly unique in R&D and healthcare. At Alexion, grow and innovate in a business with a rapidly expanding portfolio. Enjoy the entrepreneurial spirit of a leading biotech while meeting the needs of some of the most under-served patients in the world. You will be empowered with tailored development programs designed not just for skill enhancement but for fostering a deep understanding of our patient's journeys. Supported by outstanding leaders and peers ready to lift you in marketing, compliance, and beyond.

The annual base pay (or hourly rate of compensation) for this position ranges from $119,848.00 to $157,300.50. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

14-Sept-2026

Closing Date

29-Sept-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.