Senior IT Systems Engineer

10x Genomics, Inc.; Pleasanton (CA); On-site; USD 137,000 - 185,000; Full time

Benefits offered by this job

Equity grants

Health benefits

Retirement plans

Annual bonus or sales incentive

Job summary

10x Genomics, Inc. is seeking a Senior Systems Engineer to design, build, and maintain our Windows enterprise infrastructure across a global footprint. The role focuses on managing Active Directory and Entra ID, patch management, hardening, backups, and disaster recovery.

You will participate in on-call support for production systems and lead post-incident reviews to implement long-term fixes. The position requires strong scripting, IaC experience, and AWS knowledge, with opportunities for

Qualifications

• 5+ years IT experience managing Windows infrastructure and core services like AD, Entra ID, endpoint management, DNS and DHCP in production.
• Extensive virtualization experience with hypervisors (VMware ESXi/vCenter, Proxmox VE).
• Experience with system architecture and building production environments on AWS.
• Experience with enterprise backup, disaster recovery, alerting and monitoring solutions.
• Strong understanding of encryption, data security and patch management best practices.
• Experience scripting in PowerShell, Bash or Python.
• Experience with IaC and configuration management tools (Ansible, Terraform) to automate provisioning.

Responsibilities

• Design, build, maintain and monitor Windows enterprise infrastructure across global footprint.
• Manage Global Active Directory & Entra ID environment.
• Maintain a secure, stable IT environment; deploy patching, policy enforcement, hardening and upgrades.
• Manage enterprise backup and disaster recovery solutions.
• Create and maintain detailed system design and configuration documentation.
• Participate in shared on-call rotation to support production environment.
• Lead post-incident reviews to identify root causes and implement fixes.

Skills

Windows administration

Active Directory / Entra ID

VMware ESXi/vCenter

Proxmox VE

AWS

Backup & DR

Scripting: PowerShell/Bash/Python

IaC: Ansible, Terraform

Tools

Okta

Intune

Azure AD

Job description

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

About The Role

Information technology is a vital and integral part of our success. At 10x Genomics, IT not only provides a secure, stable, and scalable infrastructure for R&D, manufacturing, and business operations, it serves as a catalyst for innovation and productivity. We are looking for an exceptional Senior Systems Engineer with strong knowledge of Windows and virtualization platforms and extensive experience in building and maintaining mission-critical IT infrastructure to join our IT team. If you are a self-starter who is passionate about building and operating scalable and reliable IT infrastructure and is excited to work in a highly collaborative environment alongside a diverse team of experts every day, join us at 10x Genomics.

What you will be doing

• Design, build, maintain and monitor our mission-critical Windows enterprise infrastructure systems and services across global footprint.
• Manage our Global Active Directory & Microsoft Entra ID (formerly Azure AD) environment.
• Maintain a secure and stable IT environment; Deploying patch management software, policy enforcement, systems hardening and systems / software upgrades.
• Manage enterprise backup and disaster recovery solutions.
• Create and maintain detailed documentation of system design, implementation and configuration.
• Participate in a shared operational on-call rotation to support our production environment.
• Lead post-incident reviews to identify root causes and implement long-term preventative fixes.

Minimum Qualifications

• 5 years IT experience with managing Windows Infrastructure and core services such as Active Directory, Microsoft Entra ID, Endpoint management, DNS and DHCP in a production environment.
• Extensive experience with virtualization technologies and hypervisors, such as VMware ESXi/vCenter and Proxmox VE.
• Experience with system architecture and building production environments on AWS.
• Experience with enterprise backup, disaster recovery, alerting and monitoring solutions.
• Strong understanding of encryption, data security and patch management best practices.
• Experience scripting in Powershell, Bash or Python.
• Experience with IaC and configuration management tools (Ansible, Terraform) to automate system provisioning.

Preferred Skills & Experience

• Working knowledge of Linux such as regular day-to-day sysadmin responsibilities (build systems, management, permissions, network mounts).
• Familiar with Identity Access & Management tools (Okta, SAML2.0 / OIDC protocols).
• Familiar with Microsoft Intune for unified endpoint management and policy enforcement.
• Strong analytical and organizational skills.
• Excellent oral and written communication skills.

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

USD 136,500-184,700 / year

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.

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