Senior Infrastructure Engineer : Tell Me More

Cabaletta Bio; Philadelphia (Philadelphia County); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health insurance

401(k) with match

Stock options

Paid time off

Job summary

Cabaletta Bio is seeking a Senior Infrastructure Engineer to administer and advance our cloud and on-premises infrastructure. You will manage AWS resources, Windows and Linux servers, networking, security controls, backups, and disaster recovery, while partnering with science and business teams in a regulated biotech setting.

The role emphasizes collaboration with vendors and internal IT, driving automation, platform modernization, and reliability to support growth and compliance.

Qualifications

• Bachelor’s degree in Information Technology, Computer Science, Engineering, or a related field, or equivalent experience.
• 5+ years of progressive infrastructure administration experience.
• Experience supporting biotechnology, pharmaceutical, or life sciences organizations, including GxP-regulated environments and CSV/change control/compliance.
• Experience administering AWS cloud environments.
• Strong experience administering Linux and Windows Server environments.
• Experience supporting network infrastructure, firewalls, VPNs, DNS, etc.
• Foundational cybersecurity experience, including vulnerability remediation and access management.
• Experience supporting backup, recovery, and DR processes.
• Strong troubleshooting and communication skills.
• Ability to work independently and with cross-functional teams.

Responsibilities

• Administer and support AWS cloud infrastructure (EC2, VPCs, security groups, storage, monitoring).
• Administer, maintain, and troubleshoot Windows and Linux servers.
• Monitor performance, capacity, reliability, and participate in upgrades, patching, and lifecycle management.
• Maintain documentation, architectures, standards, and SOPs; support operational best practices.
• Support network infrastructure, firewalls, VPNs, DNS, DHCP, and wireless networking.
• Design and support cloud-native and containerized workloads (Docker, ECS, EKS).
• Assist with cloud modernization, automation, and platform engineering initiatives.
• Support data platforms, internal apps, and AI-enabled solutions infrastructure.
• Support cybersecurity controls, vulnerability remediation, and security monitoring.
• Assist in backup, disaster recovery planning, testing, and business continuity.

Skills

AWS

Linux

Windows Server

Networking

Cybersecurity

Backup & DR

Communication

Cloud platforms

Scripting

Vendor coordination

Education

Bachelor’s degree in IT/CS/Engineering or equivalent

Tools

Docker

ECS

EKS

Kubernetes

Job description

The Senior Infrastructure Engineer is responsible for the administration, maintenance, security, and continuous improvement of Cabaletta Bio’s infrastructure and cloud platforms. This role provides hands- on technical support for AWS, Windows and Linux server environments, networking, firewalls, cybersecurity controls, backup and disaster recovery capabilities, and emerging platform technologies.

The ideal candidate combines strong technical skills with excellent communication and customer service abilities, partnering effectively with scientific and business stakeholders, managed service providers, cloud partners, and internal IT resources within a regulated biotechnology environment. This position will help mature Cabaletta’s infrastructure capabilities while supporting business growth, operational readiness, and future technology initiatives.

Responsibilities Include

Infrastructure Administration

• Administer and support AWS cloud infrastructure, including EC2, VPCs, security groups, storage services, monitoring, and related cloud resources.
• Administer, maintain, and troubleshoot Windows Server and Linux server environments.
• Monitor infrastructure performance, availability, capacity, and reliability, and participate in planning, upgrades, patching, lifecycle management, and continuous improvement initiatives.
• Maintain infrastructure documentation, architecture diagrams, technical standards, and operating procedures, and assist with development and implementation of operational processes and technical best practices.

Network and Connectivity

• Support, maintain, and troubleshoot network infrastructure, including firewalls, VPN connectivity, routing, DNS, DHCP, and wireless networking services, across cloud, server, and application environments.
• Assist with network design reviews and infrastructure improvements, and collaborate with managed service providers and infrastructure vendors to resolve complex technical issues.

Cloud and Platform Services

• Design and support cloud-native and containerized workloads utilizing technologies such as Docker, ECS, EKS, and related platforms.
• Assist with application hosting, platform administration, and infrastructure services supporting internal business systems and scientific computing workloads, and participate in cloud modernization, infrastructure automation, and platform engineering initiatives.
• Support infrastructure requirements for data platforms, internal applications, and future AI-enabled solutions.

Cybersecurity and Risk Management

• Implement and maintain infrastructure security controls and cybersecurity best practices.
• Support vulnerability remediation, system hardening, patch management, access controls, and security monitoring activities.
• Review infrastructure security recommendations and assist with implementation of corrective actions, collaborating with internal and external security resources to address identified risks.
• Support security audits, assessments, and compliance initiatives as required.

Business Continuity and Disaster Recovery

• Support backup administration, recovery procedures, disaster recovery planning, and infrastructure resilience initiatives, including participation in DR exercises, testing activities, and business continuity planning.
• Maintain documentation supporting recovery procedures and infrastructure continuity requirements.

Vendor and Service Coordination

• Serve as a technical point of contact for managed service providers, cloud partners, and infrastructure vendors.
• Coordinate technical activities, projects, escalations, and support requests across external partners, reviewing vendor and partner recommendations to provide technical input and implementation support.

Customer Service and Collaboration

• Communicate effectively with business users, scientific teams, and technology partners, providing technical guidance and support during infrastructure-related incidents, projects, and technology initiatives.
• Partner closely with the Senior IT Systems Administrator and broader IT team to support enterprise technology services.

Required Qualifications

• Bachelor’s degree in Information Technology, Computer Science, Engineering, or a related field, or equivalent experience.
• 5+ years of progressive infrastructure administration experience.
• Experience supporting biotechnology, pharmaceutical, or life sciences organizations, including work within GxP-regulated environments and experience with computer system validation (CSV), change control processes, and compliance-driven operations.
• Experience administering AWS cloud environments.
• Strong experience administering Linux and Windows Server environments.
• Experience supporting network infrastructure, firewalls, VPNs, DNS, and related technologies.
• Foundational cybersecurity experience, including vulnerability remediation, system hardening, access management, and security best practices.
• Experience supporting backup, recovery, and disaster recovery processes.
• Strong troubleshooting, root cause analysis, and problem-solving skills.
• Strong written and verbal communication skills with the ability to work effectively with both technical and non-technical stakeholders.
• Ability to work independently while collaborating effectively with internal teams, vendors, and external partners.

Preferred Qualifications

• Experience supporting scientific, laboratory, clinical, manufacturing, quality, or regulatory business functions, including validated applications and infrastructure platforms.
• Experience with Docker, containerized workloads, ECS, EKS, or Kubernetes.
• Experience with infrastructure automation and scripting using PowerShell, Bash, Python, or similar technologies.
• Experience supporting hybrid cloud environments.
• AWS, Microsoft, Linux, networking, or security certifications.

Preferred Skills

Physical Requirements

• Ability to sit and work at a computer for extended periods of time.
• Ability to occasionally lift and move technology equipment weighing up to 25 pounds.
• Ability to travel occasionally between company locations, data centers, or vendor sites as needed.

Reporting Structure

• Reports to the Director, Information Technology and Data Sciences.

• Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.